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首页> 外文期刊>Journal of separation science. >Development of a highly sensitive high‐performance thin‐layer chromatography method for the screening and simultaneous determination of sofosbuvir, daclatasvir, and ledipasvir in their pure forms and their different pharmaceutical formulations
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Development of a highly sensitive high‐performance thin‐layer chromatography method for the screening and simultaneous determination of sofosbuvir, daclatasvir, and ledipasvir in their pure forms and their different pharmaceutical formulations

机译：在纯粹形式及其不同的药物制剂中筛选和同时测定Sofosbuvir，Daclatasvir和Ledipasvir的筛选和同时测定高度敏感的高性能薄层色谱法。及其不同的药物制剂

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Abstract >The combination of sofosbuvir and daclatasvir or sofosbuvir and ledipasvir is now widely used as an ideal treatment for hepatitis C virus infection. For this purpose, a simple, sensitive, accurate, economic, and precise high‐performance thin‐layer chromatography was developed and validated for the determination of sofosbuvir, daclatasvir, and ledipasvir in their pure form as well as their different pharmaceutical products. The method used Merck high‐performance thin‐layer chromatography aluminum plates precoated with silica gel 60 F254 as a stationary phase and mobile phase consisting of methylene chloride/methanol/ethyl acetate/ammonia (25%) (6:1:4:1, v/v/v/v). This system was found to give compact symmetric peaks of sofosbuvir, daclatasvir, and ledipasvir with retardation factors of 0.27 ± 0.01, 0.50 ± 0.007, and 0.68 ± 0.008, respectively. The densitometric scanner was set at 275?nm using a deuterium lamp. The calibration curves were linear over the range of 100–3000?ng/spot for sofosbuvir, and daclatasvir, and range of 50–3000?ng/spot for ledipasvir. The detection limits were 22.5, 31.90, and 15.80 for sofosbuvir, daclatasvir, and ledipasvir. The quantitation limits were 67.50, 95.60, and 47.50 for sofosbuvir, daclatasvir, and ledipasvir. The proposed method was validated according to International Conference on Harmonization (ICH) guidelines and the results were acceptable. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <title类型=“main”>抽象</ title> > Sofosbuvir和Daclatasvir或Sofosbuvir和Ledipasvir的组合现在被广泛用作理想的治疗丙型肝炎病毒感染。为此目的，开发了一种简单，敏感，准确，经济和精确的高性能薄层色谱，并验证了纯形式的Sofosbuvir，Daclatasvir和Ledipasvir以及其不同的药物产品。该方法使用硅胶60f254硅胶铝合金铝板作为固定相和流动相，由二氯甲烷/甲醇/乙酸乙酯/氨（25％）（6：1：4：1）组成。 v / v / v / v）。发现该系统具有Sofosbuvir，Daclatasvir和Ledipasvir的紧凑型对称峰，延迟因子分别为0.27±0.01,0.5.50±0.007和0.68±0.008。使用氘灯设置密度计量扫描仪。校准曲线是线性的，范围为100-3000？Sofosbuvir，Daclatasvir的Ng /斑点，以及50-3000的范围为50-3000？Ng / Spot for LEDIPASVIR。检测限为Sofosbuvir，Daclatasvir和Ledipasvir的22.5,31.90和15.80。 Sofosbuvir，Daclatasvir和Ledipasvir的定量限制为67.50,95.60和47.50。拟议的方法是根据国际协调会议（ICH）指南的验证，结果是可接受的。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-35800/'>《Journal of separation science.》</a> <b style="margin: 0 2px;">|</b><span>2018年第18期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Saraya Roshdy E.&option=202" target="_blank" rel="nofollow">Saraya Roshdy E.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Elhenawee Magda&option=202" target="_blank" rel="nofollow">Elhenawee Magda;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Saleh Hanaa&option=202" target="_blank" rel="nofollow">Saleh Hanaa;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Pharmaceutical Analytical Chemistry Faculty of PharmacyPort Said UniversityPort Said Egypt;</p> <p>Department of Pharmaceutical Analytical Chemistry Faculty of PharmacyZagazig UniversityZagazig Egypt;</p> <p>Department of Pharmaceutical Analytical Chemistry Faculty of PharmacyZagazig UniversityZagazig Egypt;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/159.html" title="化学">化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=daclatasvir&option=203" rel="nofollow">daclatasvir;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=high‐performance thin layer chromatography&option=203" rel="nofollow">high‐performance thin layer chromatography;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=ledipasvir&option=203" rel="nofollow">ledipasvir;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=mpiviropack&option=203" rel="nofollow">mpiviropack;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=sofosbuvir&option=203" rel="nofollow">sofosbuvir;</a> </p> <div class="translation"> 机译：Daclatasvir;高性能薄层色谱;LEDIPASVIR;MPIVIROPACK;SOFOSBUVIR; 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