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首页> 外文期刊>Journal of separation science. >Application of response surface methodology to vortex‐assisted dispersive liquid–liquid extraction for the determination of nicotine and cotinine in urine by gas chromatography–tandem mass spectrometry
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Application of response surface methodology to vortex‐assisted dispersive liquid–liquid extraction for the determination of nicotine and cotinine in urine by gas chromatography–tandem mass spectrometry

机译：响应面方法在涡旋辅助分散液 - 液萃取液相色谱 - 串联质谱法测定尿液辅助分散液 - 液萃取

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Abstract > A method of vortex‐assisted dispersive liquid–liquid extraction coupled with gas chromatography and tandem mass spectrometry for the determination of nicotine and cotinine in urine was developed. Response surface methodology was applied to obtain the optimum extraction conditions. In this method, Plackett–Burman design was utilized to evaluate the impact of five selected factors on pretreatment procedure. Then, three main factors were optimized using a Box–Behnken design. The optimized method showed good linearities at 1–2000?μg/L with correlation coefficients of 0.9998 for nicotine and 0.9986 for cotinine. Recovery was 91.4–106 and 91.7–108% for nicotine and cotinine, respectively. The intraday relative standard derivations of determination were 1.47–4.06% for nicotine and 0.41–3.16% for cotinine, and interday relative standard derivations were 3.03–6.70% for nicotine and 1.64–6.38% for cotinine. The method detection limits for nicotine and cotinine were 0.33 and 0.34?μg/L, respectively. A total of 87 urine samples from smokers and nonsmokers were tested with the proposed method. Urinary nicotine and cotinine were 23.0–6.67 × 10 3 and 18.4–4.17 × 10 3 ?μg/(g·cr) for smokers and 1.31–286 and 1.39–131?μg/(g·cr) for nonsmokers, respectively. The method is sensitive, suitable and reliable for the determination of nicotine and cotinine in urine and meets the requirements for evaluating short‐term tobacco exposure. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >涡旋辅助分散液 - 液 - 液 - 液萃取方法与气相色谱和串联质谱相结合为了确定尿液和尿液中的尿苷的测定。应用响应面方法，以获得最佳提取条件。在这种方法中，利用Plackett-Burman设计来评估五种选定因子对预处理程序的影响。然后，使用Box-Behnken设计进行了三种主要因素。优化方法在1-2000Ω·μg/ L的情况下显示出良好的线性，其相关系数为0.9998，尼古丁为0.9986，用于胞苷。尼古丁和枸杞分别回收率为91.4-106和91.7-108％。尼古丁的测定中的内部相对标准衍生物为1.47-4.06％，尼古丁的尼古丁为0.41-3.16％，尼古丁的相对标准衍生物为3.03-6.70％，胞苷的1.64-6.38％。尼古丁和枸杞的方法检测限分别为0.33和0.34ΩΩ·μg/ L.用所提出的方法测试了吸烟者和非吸烟者的87个尿液样本。吸烟者的尿尼古丁和枸杞和18.4-4.17×10 3 </ sup>μg/（g·cr）和1.31-286和1.39-131 μg/（g·cr）分别用于非闻名者。该方法对尿液中的尼古丁和胞苷的测定是敏感的，适当可靠，满足评估短期烟草暴露的要求。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-35800/'>《Journal of separation science.》</a> <b style="margin: 0 2px;">|</b><span>2018年第10期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yuan Yue&option=202" target="_blank" rel="nofollow">Yuan Yue;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Yan&option=202" target="_blank" rel="nofollow">Wang Yan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Mingqi&option=202" target="_blank" rel="nofollow">Yang Mingqi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xu Yicong&option=202" target="_blank" rel="nofollow">Xu Yicong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Weina&option=202" target="_blank" rel="nofollow">Chen Weina;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zou Xiaoli&option=202" target="_blank" rel="nofollow">Zou Xiaoli;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zheng Bo&option=202" target="_blank" rel="nofollow">Zheng Bo;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Sanitary TechnologyUniversity of SichuanChengdu P. R. China;</p> <p>Department of Sanitary TechnologyUniversity of SichuanChengdu P. R. China;</p> <p>Department of Sanitary TechnologyUniversity of SichuanChengdu P. R. China;</p> <p>Department of Sanitary TechnologyUniversity of SichuanChengdu P. R. China;</p> <p>Department of Sanitary TechnologyUniversity of SichuanChengdu P. R. China;</p> <p>Department of Sanitary TechnologyUniversity of SichuanChengdu P. R. China;</p> <p>Department of Sanitary TechnologyUniversity of SichuanChengdu P. R. China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/159.html" title="化学">化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cotinine&option=203" rel="nofollow">cotinine;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=gas chromatography&option=203" rel="nofollow">gas chromatography;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=nicotine&option=203" rel="nofollow">nicotine;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=response surface methodology&option=203" rel="nofollow">response surface methodology;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=vortex‐assisted dispersive liquid–liquid extraction&option=203" rel="nofollow">vortex‐assisted dispersive liquid–liquid extraction;</a> </p> <div class="translation"> 机译：cotinine;气相色谱;尼古丁;响应面方法;涡旋辅助分散液 - 液提取; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025845953.html">Application of response surface methodology to vortex‐assisted dispersive liquid–liquid extraction for the determination of nicotine and cotinine in urine by gas chromatography–tandem mass spectrometry</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yuan Yue&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yuan Yue,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Yan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wang Yan,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Mingqi&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yang Mingqi,</a> <a href="/journal-foreign-35800/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of separation science. .</a> <span>2018</span><span>,第10期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：响应面方法在涡旋辅助分散液 - 液萃取液相色谱 - 串联质谱法测定尿液辅助分散液 - 液萃取</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704020640126.html">Ionic liquid based vortex assisted liquid-liquid microextraction combined with liquid chromatography mass spectrometry for the determination of bisphenols in thermal papers with the aid of response surface methodology</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Asati Ankita&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Asati Ankita,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Satyanarayana G. 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A. </a> <span>2007</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：美国地质调查局有机地球化学研究组分析方法：采用固相萃取和液相色谱/串联质谱法测定水中溶解的异恶唑草酮及其顺序降解产物，二酮腈和苯甲酸</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201297813814.html">分散固相萃取-超声辅助分散液液微萃取/高效液相色谱法测定土壤中溴氰菊酯残留</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=于玲&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 于玲</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=董丽丽&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,董丽丽</a> <span> <a href="/journal-cn-57080/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 分析科学学报 </a> </span> <span> . 2016</span><span>,第2期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-instrumental-analysis_thesis/0201278661609.html">基于低共熔溶剂的涡旋辅助悬浮固化-分散液液微萃取/高效液相色谱法测定水中三氯生与三氯卡班</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈梦轩&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 陈梦轩</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=吴友谊&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,吴友谊</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=周韫璐&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,周韫璐</a> <span> <a href="/journal-cn-10803/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 分析测试学报 </a> </span> <span> . 2020</span><span>,第004期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-instrumental-analysis_thesis/0201230476572.html">涡旋辅助分散液液微萃取-悬浮固化/高效液相色谱法测定水样中7种萘二酚</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=许丽珠&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 许丽珠</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李秀英&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李秀英</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=冼燕萍&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,冼燕萍</a> <span> <a href="/journal-cn-10803/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 分析测试学报 </a> </span> <span> . 2015</span><span>,第008期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-analytical-chemistry_thesis/0201271876507.html">酸辅助分散液液微萃取-高效液相色谱-串联质谱法测定果汁中多种真菌毒素</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=韩艺烨&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 韩艺烨</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=邓年&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,邓年</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=谢建军&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,谢建军</a> <span> <a href="/journal-cn-10804/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 分析化学 </a> </span> <span> . 2019</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_china-oils-fats_thesis/0201275789799.html">超声辅助-分散液液微萃取/快速液相色谱-串联质谱法测定食用植物油中黄曲霉毒素</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=朱筱玲&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 朱筱玲</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵淑娥&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,赵淑娥</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=罗春丽&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,罗春丽</a> <span> <a href="/journal-cn-9445/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国油脂 </a> </span> <span> . 2019</span><span>,第011期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-2134_thesis/02022404117.html">涡旋辅助液液分散微萃取-高效液相色谱荧光检测快速测定水中的双酚A</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xiao Yang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Xiao Yang</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨肖&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨肖</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xiao-yuan Ding&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Xiao-yuan Ding</a> <span> <a href="/conference-cn-2134/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2014第三届环渤海色谱质谱学术报告会 </a> <span> <span> . 2014</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020311604571.html">超声辅助分散液-液微萃取/高效液相色谱联用测定环境水样中的有机污染物</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王青&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王青</a> <span> . 2013</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061204028929.html">疏水性低共熔溶剂涡旋辅助分散液液微萃取-高效液相色谱法检测苏丹红I的方法</a> <b>[P]</b> . <span> 中国专利： CN108572231B </span> <span> . 2020.10.02</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/061203966075.html">疏水性低共熔溶剂涡旋辅助分散液液微萃取-高效液相色谱法检测甲醛的方法</a> <b>[P]</b> . <span> 中国专利： CN108593808B </span> <span> . 2020.11.06</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130430416870.html">Quantitative determination of Risedronate in urine by SPE - LC - MS - MS. Solid phase extraction - High Performance Liquid Chromatography - mass spectrometry.</a> <b>[P]</b> . <span> 外国专利： <!-- --> AR065598A1 </span> <span> . 2009-06-17</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过SPE-LC-MS-MS定量测定尿中的Riseronate。固相萃取-高效液相色谱-质谱。 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130412929132.html">MULTIDRUG ANALYSIS IN URINE BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY</a> <b>[P]</b> . <span> 外国专利： <!-- 美国专利： --> US2016231341A1 </span> <span> . 2016-08-11</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：液相色谱-串联质谱法测定尿液中的多药 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130414203009.html">METHOD FOR ANALYZING PORPHYRIN IN URINE AND PLASMA BY USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY</a> <b>[P]</b> . <span> 外国专利： <!-- 韩国专利： --> KR20150070484A </span> <span> . 2015-06-25</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：液相色谱-串联质谱法测定尿液和血浆中卟啉的方法 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704025845953','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div 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