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首页> 外文期刊>Journal of separation science. >Screening, separation, and evaluation of xanthine oxidase inhibitors from Paeonia lactifloraPaeonia lactiflora using chromatography combined with a multi‐mode microplate reader
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Screening, separation, and evaluation of xanthine oxidase inhibitors from Paeonia lactifloraPaeonia lactiflora using chromatography combined with a multi‐mode microplate reader

机译：使用色谱法与多模微孔板读卡器联合来自芍药酶抑制剂的筛选，分离和评估芍药酶抑制剂的芍药酶抑制剂

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Abstract > Natural products have become one of the most important resources for discovering novel xanthine oxidase inhibitors, which are commonly employed in the treatment of hyperuricemia and gout. However, to date, few reports exist regarding the use of monoterpene glycosides as xanthine oxidase inhibitors. Thus, we herein report the use of ultrafiltration coupled with liquid chromatography in the screening of monoterpene glycoside xanthine oxidase inhibitors from the extract of Paeonia lactiflora ( P. lactiflora ), and both high‐performance counter‐current chromatography and medium‐pressure liquid chromatography were employed to separate the main constituents. Furthermore, the xanthine oxidase inhibitory activities and the mechanisms of inhibition of the isolated compounds were evaluated using a multi‐mode microplate reader by Molecular Devices. As a result, three monoterpene glycosides were separated by combined high‐performance counter‐current chromatography and medium‐pressure liquid chromatography in purities of 90.4, 98.0, and 86.3%, as determined by liquid chromatography. These three compounds were identified as albiflorin, paeoniflorin, and 1‐ O ‐β‐?‐glucopyranosyl‐8‐ O ‐benzoylpaeonisuffrone by electrospray ionization tandem mass spectrometry, and albiflorin and paeoniflorin were screened as potential xanthine oxidase inhibitors by ultrafiltration with liquid chromatography. The evaluation results of xanthine oxidase inhibitory activity corresponded with the screening results, as only albiflorin and paeoniflorin exhibited xanthine oxidase inhibitory activity. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >天然产品已成为发现新型黄嘌呤氧化酶抑制剂最重要的资源之一，即常用于治疗高温血症和痛风。然而，迄今为止，存在关于使用单萜糖苷作为黄嘌呤氧化酶抑制剂的报道。因此，我们在此报告使用超滤与液相色谱相结合，在筛选单萜糖苷黄嘌呤氧化酶抑制剂中，来自芍药菌的提取物（ p.1.1），两者都是使用高性能逆流色谱和中压液相色谱法分离主要成分。此外，通过分子装置使用多模微相液读取器评估三原氨酸氧化酶抑制活性和抑制分离的化合物的机制。结果，通过液相色谱法测定，通过组合高性能反电流色谱和中压液相色谱法分离三种单萜糖苷和中压液相色谱分离。将这三种化合物鉴定为苯丙脲，芍药蛋白和1- -β-β - β - β-β-β-β-β-β-β-β-β-β-β-β-β-β-·苯甲酰甲基葡萄球菌，并通过电喷雾电离串联质谱法，以及苯丙脲和通过用液相色谱法筛选促芍药蛋白作为潜在的黄嘌呤氧化酶抑制剂。黄嘌呤氧化酶抑制活性的评价结果​​与筛选结果相对应，只有苯氯和芍药蛋白表现出黄嘌呤氧化酶抑制活性。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-35800/'>《Journal of separation science.》</a> <b style="margin: 0 2px;">|</b><span>2017年第21期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Jing&option=202" target="_blank" rel="nofollow">Wang Jing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shi Dongfang&option=202" target="_blank" rel="nofollow">Shi Dongfang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zheng Meizhu&option=202" target="_blank" rel="nofollow">Zheng Meizhu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ma Bing&option=202" target="_blank" rel="nofollow">Ma Bing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cui Jing&option=202" target="_blank" rel="nofollow">Cui Jing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Chunming&option=202" target="_blank" rel="nofollow">Liu Chunming;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Chengyu&option=202" target="_blank" rel="nofollow">Liu Chengyu;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>The Central LaboratoryChangchun Normal UniversityChangchun China;</p> <p>The Central LaboratoryChangchun Normal UniversityChangchun China;</p> <p>The Central LaboratoryChangchun Normal UniversityChangchun China;</p> <p>The Central LaboratoryChangchun Normal UniversityChangchun China;</p> <p>The Central LaboratoryChangchun Normal UniversityChangchun China;</p> <p>The Central LaboratoryChangchun Normal UniversityChangchun China;</p> <p>Clinical Department of RehabilitationChangchun University of Chinese MedicineChangchun China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/159.html" title="化学">化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=monoterpene glycosides&option=203" rel="nofollow">monoterpene glycosides;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=natural products&option=203" rel="nofollow">natural products;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=screening&option=203" rel="nofollow">screening;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=xanthine oxidase inhibitors&option=203" rel="nofollow">xanthine oxidase inhibitors;</a> </p> <div class="translation"> 机译：单萜糖苷;天然产品;筛选;黄嘌呤氧化酶抑制剂; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a 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