Immunophenotypic Stability of CD200 Expression in Plasma Cell Myeloma.

摘要

We read with interest the article "Diagnostic Usefulness and Prognostic Impact of CD200 Expression in Lymphoid Malignancies and Plasma Cell Myeloma" by Alapat et al. The authors presented as one of their findings flow cytometric data on CD200 expression in 52 cases of plasma cell myeloma (PCM), and the proportion of CD200+ cases (71%) was similar to that previously reported by our group (in a cohort of 76 patients) and by other authors. In addition, the authors correlated CD200 immunophenotypic expression findings with gene expression profiling (GEP) information; of 27 patients with serial GEP analyses, 5 (19%) had a change in CD200 gene expression, and this change (particularly loss of CD200 expression) may have occurred during disease progression. However, no serial evaluation of CD200 expression by flow cytometry (FC) was available in their cohort.