Sorption of Ra-223 and Pb-211 on modified nanodiamonds for potential application in radiotherapy

摘要

Ra-223 and Pb-211/Bi-211 radionuclides with radiochemical purity were obtained from Ac-227/Ra-223 generator on DGA resin. Covalent grafting of organic complexons (ethylenediaminetetraacetic acidEDTA and derivatives of amino acidsL1 and L2 to aminated nanodiamonds (ND) was performed by carbodiimide method. Adsorption behavior of Ra and Pb in plasma volume expander on modified nanodiamonds was studied in detail. Effective adsorption have been found for Pb-211 in physiologically acceptable conditions. Sorption behavior of generator radionuclides Ra-223 and Pb-211 on the surface of ND-L1 and ND-L2 in aqueous solution (pH=6.3) was studied. It was shown that the labeling yield of Pb-211 from the solution was about 94%. The sorption of Ra-223 under the same conditions was weak. The sorption/desorption kinetics of Pb-211 on the surface of ND-EDTA in the plasma volume expander was studied. The desorption rate of Pb-211 did not exceed 2.5% within 60min (pH 7.2-7.4).