Estimation of Sc-47 and Lu-177 production rates from their natural targets in Kyoto University Research Reactor

摘要

To assess the capability of Kyoto University Research Reactor to supply the domestic needs of medical isotopes, its neutron flux has been fully characterized. The production rates of theranostics radionuclides Lu-177 (from Lu-176 (n, gamma) Lu-177), Lu-176 (n, gamma) Lu-177m/Lu-177 and Yb-176 (n, gamma) 177Yb & x27f6;beta-(1.88hr)177Lu , and Sc-47 (from Ca-46 (n, gamma) 47Ca & x27f6;beta-(4.54d)47Sc and Ti (n, p) Sc-47) were evaluated. The activity (per gram of target) of Sc-47 produced from Ti was found to be 10 times higher than that produced from Ca. Production of Lu-177 from the decay of its isomer Lu-177m was found to be produce less radioactive wastes than Yb route and can be used as a generator for long-time use.