Effect of adoptive transfer of CD4(+)CD25(+)Foxp3(+) Treg induced by trichostatin A on the prevention of spontaneous abortion

Wang Jian; Yang Jing; Yan Yuqing; Zhu Zhuangyan; Mu Yaqin; Wang Xiying; Zhang Jinhua; Liu Lihua; Zhao Fuxi; Chi Yuling

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Effect of adoptive transfer of CD4(+)CD25(+)Foxp3(+) Treg induced by trichostatin A on the prevention of spontaneous abortion

机译：CD4（+）CD25（+）Foxp3（+）Treg诱导的CD4（+）CD25（+）Treg的效果对预防自发流产的影响

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Objective: To investigate whether epigenetic modification of CD4(+)CD25(-) T-cells in vitro can make up for the inadequacy of CD4(+)CD25(+)Foxp3(+) Treg in animal model of spontaneous abortion and prevent immune response-mediated spontaneous abortion.

机译：目的：探讨在体外CD4（+）CD25（ - ）T细胞的表观遗传改性是否可以弥补自发流产动物模型中CD4（+）CD25（+）Foxp3（+）Treg的不足，并防止免疫响应介导的自发流产。

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来源
《Journal of Reproductive Immunology》 |2019年第2019期|共6页
作者
Wang Jian; Yang Jing; Yan Yuqing; Zhu Zhuangyan; Mu Yaqin; Wang Xiying; Zhang Jinhua; Liu Lihua; Zhao Fuxi; Chi Yuling;
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作者单位

Shanxi Datong Univ Inst Immunol 1 Xinyun St Datong 037009 Shanxi Peoples R China;

Fifth Peoples Hosp Dept Hematol Datong 037009 Shanxi Peoples R China;

Shanxi Datong Univ Dept Biochem Med Coll Datong 037009 Shanxi Peoples R China;

Shanxi Datong Univ Inst Immunol 1 Xinyun St Datong 037009 Shanxi Peoples R China;

Shanxi Datong Univ Inst Immunol 1 Xinyun St Datong 037009 Shanxi Peoples R China;

Shanxi Datong Univ Inst Immunol 1 Xinyun St Datong 037009 Shanxi Peoples R China;

Fifth Peoples Hosp Dept Hematol Datong 037009 Shanxi Peoples R China;

Shanxi Datong Univ Inst Immunol 1 Xinyun St Datong 037009 Shanxi Peoples R China;

Shanxi Datong Univ Inst Immunol 1 Xinyun St Datong 037009 Shanxi Peoples R China;

Albert Einstein Coll Med Dept Med Bronx NY 10461 USA;

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正文语种 eng
中图分类妇科学;
关键词
Unexplained recurrent spontaneous abortion; Histone modification; Trichostatin A; CD4(+)CD25(+)Foxp3(+) Treg; Adoptive transfer; Embryo resorption rate;

机译：无法解释的复发性自发性流产;组蛋白修饰;richostatina;CD4（+）CD25（+）Foxp3（+）Treg;收养转移;胚胎吸收率;

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专利

1. Effect of adoptive transfer of CD4(+)CD25(+)Foxp3(+) Treg induced by trichostatin A on the prevention of spontaneous abortion [J] . Wang Jian, Yang Jing, Yan Yuqing, Journal of Reproductive Immunology . 2019,第期

机译：CD4（+）CD25（+）Foxp3（+）Treg诱导的CD4（+）CD25（+）Treg的效果对预防自发流产的影响
2. Adoptive transfer of CD4 +CD25 + regulatory T cells for prevention and treatment of spontaneous abortion [J] . YinY., HanX., ShiQ., European Journal of Obstetrics, Gynecology and Reproductive Biology: An International Journal . 2012,第2期

机译：过继转移CD4 + CD25 +调节性T细胞用于预防和治疗自然流产
3. Adoptive transfer of transforming growth factor-1-induced CD4(+)CD25(+) regulatory T cells prevents immune response-mediated spontaneous abortion [J] . Qiu Tian, Teng Yincheng, Wang Yudong, Reproduction, fertility, and development . 2016,第11期

机译：转化生长因子1诱导的CD4（+）CD25（+）调节性T细胞的过继转移可阻止免疫应答介导的自然流产
4. Expression of CD4+CD25+ T regulatory cells and Foxp3 in peripheral blood of patients with Rheumatoid Arthritis Patient [C] . Kexin Sun, Yan Li, Suhong Guo, International Conference on Applied Science, Engineering and Technology . 2013

机译：类风湿性关节炎患者外周血CD4 + CD25 + T调节细胞和FOXP3的表达
5. Endogenous antitumor immunity elicited by adoptively transferred lymphocytes through CCL5 and CD40L signaling, and dendritic cell depletion. [D] . Nesbeth, Yolanda C. 2010

机译：过继转移的淋巴细胞通过CCL5和CD40L信号传导以及树突状细胞耗竭引发内源性抗肿瘤免疫力。
6. Adoptive Transfers of CD4+CD25+ Tregs Raise Foxp3 Expression and Alleviate Mouse Enteritis [O] . Kai Wang, Tongjia Zhu, Haijun Wang, -1

机译：CD4 + CD25 + Treg的过继转移可提高Foxp3表达并减轻小鼠肠炎
7. Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease [O] . Zeiser, Robert, Nguyen, Vu H., Hou, Jing-Zhou, 2007

机译：早期CD30信号传导对于过继转移CD4 + CD25 +调节性T细胞在预防急性移植物抗宿主病中至关重要

Effect of adoptive transfer of CD4(+)CD25(+)Foxp3(+) Treg induced by trichostatin A on the prevention of spontaneous abortion

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