Anticaries potential of a stabilized stannous-containing sodium fluoride dentifrice

摘要

Purpose: To evaluate the anticaries potential of a stabilized stannous-containing sodium fluoride dentifrice relative to appropriate control products. Methods: A series of in vitro studies was conducted using the following standard anticaries efficacy measures: (1) fluoride uptake; (2) pH cycling remineralization/inhibition of demineralization; and (3) surface microhardness. In each study, the stannous-containing sodium fluoride test dentifrice (1450 ppm F) was compared to a negative control dentifrice (0 ppm F) and a positive control fluoride dentifrice (either 1100 ppm F or 1450 ppm F). Results: Fluoride uptake: The mean fluoride uptake from both the test dentifrice and the positive control dentifrice was significantly greater than the negative control. There was no statistically significant difference between the two fluoride dentifrices, although the test dentifrice was directionally higher. pH cycling: The remineralization measured with the test dentifrice was directionally higher though not significantly different from the positive control dentifrice. Remineralization by both fluoride-containing dentifrices was significantly greater versus the negative control. Surface microhardness: The percent increase in surface microhardness measured on enamel surfaces after treatments with the test dentifrice was found to be significantly higher than that measured for the positive control and the negative control.