<fc xmlns='http://www.wiley.com/namespaces/wiley'>SERS</fc>SERS analysis of selectively captured exosomes using an integrin‐specific peptide ligand

Lee Changwon; Carney Randy; Lam Kit; Chan James W.

摘要

Abstract > We demonstrate selective capturing of exosomes for surface‐enhanced Raman spectroscopy (SERS) analysis using a thiolated peptide ligand that is bound to the surface of silver nanoparticles via thiol‐metallic bond formation. The ligand preferentially binds to α3?1 integrin over‐expressed in exosomes secreted from SKOV‐3 cancer cells. Several Raman peaks at 894?cm ?1 , 1,080?cm ?1 , 1,252?cm ?1 , 1,340?cm ?1 , and 1,380?cm ?1 specific to SKOV‐3 exosomes are detected above the background signals generated from the nanoparticle and the ligand. In comparison, α3?1 integrin negative exosomes secreted from Jurkat cells showed no detectable exosome specific SERS signal, confirming the high specificity of this ligand‐based SERS detection approach. This study shows the potential of developing a target‐specific SERS detection approach for characterizing exosomes from a heterogeneous mixture in body fluid for early‐stage disease diagnostics. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> >我们展示使用硫醇化肽配体的表面增强拉曼光谱（SERS）分析的选择性捕获外来的磷酸纤维素分析，所述硫醇化肽配体通过硫醇 - 金属键形成结合在银纳米粒子的表面上。配体优先结合来自来自Skov-3癌细胞分泌的外泌体以α3α1的整联蛋白结合。几个拉曼峰在894？cm 1/1 / sup>，1,080？cm α1</ sup>，1,252？cm 1 </ sup>，1,340？cm ？在从纳米颗粒和配体产生的背景信号之上，检测到SKOV-3外索体的1 </ sup>和1,380厘米 1/4 / sup>。相比之下，α3？1整联蛋白的阴性外来肌瘤细胞分泌，显示出没有可检测的外渗特异性SERs信号，证实了基于配体的SERS检测方法的高特异性。该研究表明，开发靶特异性SERS检测方法的可能性，用于表征来自体液中的异质混合物以进行早期疾病诊断。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-35645/'>《Journal of Raman Spectroscopy: An International Journal for Original Work in All Aspects of Raman Spectroscopy, Including Higher Order Processes, and Also Brillouin- and Rayleigh Scattering》</a> <b style="margin: 0 2px;">|</b><span>2017年第12期</span><b style="margin: 0 2px;">|</b><span>共6页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lee Changwon&option=202" target="_blank" rel="nofollow">Lee Changwon;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Carney Randy&option=202" target="_blank" rel="nofollow">Carney Randy;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lam Kit&option=202" target="_blank" rel="nofollow">Lam Kit;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chan James W.&option=202" target="_blank" rel="nofollow">Chan James W.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Center for BiophotonicsUniversity of California DavisSacramento CA 95817 USA;</p> <p>Department of Biochemistry and Molecular MedicineUniversity of California DavisSacramento CA 95817 USA;</p> <p>Department of Biochemistry and Molecular MedicineUniversity of California DavisSacramento CA 95817 USA;</p> <p>Center for BiophotonicsUniversity of California DavisSacramento CA 95817 USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/4724.html" title="光谱学">光谱学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=exosomes&option=203" rel="nofollow">exosomes;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=nanoparticles&option=203" rel="nofollow">nanoparticles;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=spectroscopy&option=203" rel="nofollow">spectroscopy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=surface‐enhanced Raman scattering&option=203" rel="nofollow">surface‐enhanced Raman scattering;</a> </p> <div class="translation"> 机译：外来;纳米粒子;光谱;表面增强拉曼散射; </div> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> 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SERSSERS analysis of selectively captured exosomes using an integrin‐specific peptide ligand

摘要