Effects of Sedative Agent JM-1232(-) ((-)-3-(2-(4-methyl-l-piperazinyl)-2-oxoethyl)-2-phenyl-3,5,6,7-tetrahydrocyclopenta(flisoindole-l(2H)-one) on the Carotid Arteries of Rats

摘要

In the present study, we investigate whether JM-1232(-) ((-)-3-[2-(4-methyl-l-piperazinyl)-2-oxoethyl]-2-phenyl-3,5,6,7-tetrahydrocyclopenta[fJisoindole-1 (2H)-one) affects vessels directly or indirectly. We examined the effects of JM-1232(-) with several antagonists on rat carotid arteries using the Magnus method. JM-1232 (-) suppressed contraction non-specifically on norepinephrine, potassium chloride and calcium chloride at a high concentration (E_max: 10~-5-10~-4 M). There were no significant change in each pretreated group consisting of flumazenil, propranolol, atropine, cimetidine, imetit and N(omega)-nitro-L-arginine methyl ester, whereas a significant suppression was observed (p<0.05) in PK11195 (50% inhibition concentration (IC_50): 3.2+-0.9 (xl0~-5) M) and diphenhydramine (IC_50: 5.6+-1.7 (x10~-5) M).