Application of Physiologically-Based Oral Absorption & Pharmacokinetic Modeling to Investigate Formulation Factors Influencing the Pharmacokinetics of Novel Oral Anticoagulants

Farhan Nashid; Basu Sumit; Kim Sarah; Lingineni Karthik; Vozmediano Valvanera; Ait-Oudhia Sihem; Fang Lanyan; Zhao Liang; Lesko Lawrence; Schmidt Stephan

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Application of Physiologically-Based Oral Absorption & Pharmacokinetic Modeling to Investigate Formulation Factors Influencing the Pharmacokinetics of Novel Oral Anticoagulants

机译：基于生理学的口腔吸收和药代动力学建模对影响新型口腔抗凝剂药代动力学的制剂因素的应用

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来源
《Journal of pharmacokinetics and pharmacodynamics 》 |2018年第suppla期| 共1页
作者
Farhan Nashid; Basu Sumit; Kim Sarah; Lingineni Karthik; Vozmediano Valvanera; Ait-Oudhia Sihem; Fang Lanyan; Zhao Liang; Lesko Lawrence; Schmidt Stephan;
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作者单位

Univ Florida Coll Pharm Ctr Pharmacometr &

Syst Pharmacol Orlando FL USA;

Univ Florida Coll Pharm Ctr Pharmacometr &

Syst Pharmacol Orlando FL USA;

Univ Florida Coll Pharm Ctr Pharmacometr &

Syst Pharmacol Orlando FL USA;

Univ Florida Coll Pharm Ctr Pharmacometr &

Syst Pharmacol Orlando FL USA;

Univ Florida Coll Pharm Ctr Pharmacometr &

Syst Pharmacol Orlando FL USA;

Univ Florida Coll Pharm Ctr Pharmacometr &

Syst Pharmacol Orlando FL USA;

US FDA Off Res &

Stand Off Gener Drugs Ctr Drug Evaluat &

Res Silver Spring MD USA;

US FDA Off Res &

Stand Off Gener Drugs Ctr Drug Evaluat &

Res Silver Spring MD USA;

Univ Florida Coll Pharm Ctr Pharmacometr &

Syst Pharmacol Orlando FL USA;

Univ Florida Coll Pharm Ctr Pharmacometr &

Syst Pharmacol Orlando FL USA;

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原文格式 PDF
正文语种 eng
中图分类药学 ;
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专利

1. Application of Physiologically-Based Oral Absorption & Pharmacokinetic Modeling to Investigate Formulation Factors Influencing the Pharmacokinetics of Novel Oral Anticoagulants [J] . Farhan Nashid, Basu Sumit, Kim Sarah, Journal of pharmacokinetics and pharmacodynamics . 2018 ,第Suppla期

机译：基于生理学的口腔吸收和药代动力学建模对影响新型口腔抗凝剂药代动力学的制剂因素的应用
2. Food Effects on Oral Drug Absorption: Application of Physiologically-Based Pharmacokinetic Modeling as a Predictive Tool [J] . Lisa Cheng, Harvey Wong Pharmaceutics . 2020 ,第7期

机译：对口腔吸毒的食物作用：基于生理学药代理建模的应用作为预测工具
3. Evaluating the Role of Solubility in Oral Absorption of Poorly Water-Soluble Drugs Using Physiologically-Based Pharmacokinetic Modeling [J] . Fink Christina, Sun Dajun, Wagner Knut, Clinical Pharmacology and Therapeutics . 2020 ,第3期

机译：使用生理基于生理学药代动力学建模来评估溶解度在口服吸收中的溶解度的作用
4. Influence of Particle Size on Bioavailability and Rate of Absorption For Oral Dosage Forms Prepared From Poorly Water Soluble Drugs: A Comparison Between in-silico, in-vitro and invivo Pharmacokinetic Data. [C] . Annual meeting exposition of the Controlled Release Society . 2009

机译：粒度对水溶性药物不良制备的口服剂型生物利用度的影响及其吸收率：硅，体外和Invivo药代动力学数据的比较。
5. 1. Pharmacokinetic modeling and simulations of gastrointestinal transit effects on drug pharmacokinetics from enteric-coated pellet formulations and their applications. 2. Development of crushable enteric-coated formulations. 3. Development of leaky enteric-coated pellets formulations. [D] . Watanalumlerd, Prapoch. 2004

机译：1.胃肠道转运对肠溶微丸制剂中药物药代动力学的影响的药代动力学建模和模拟及其应用。 2.开发可压碎的肠溶衣制剂。 3.开发泄漏的肠溶丸剂。
6. Food Effects on Oral Drug Absorption: Application of Physiologically-Based Pharmacokinetic Modeling as a Predictive Tool [O] . Lisa Cheng, Harvey Wong 2020

机译：对口腔吸毒的食物作用：基于生理学药代理建模的应用作为预测工具
7. Analysis of the impact of controlled release formulation on oral drug absorption, gut wall metabolism and relative bioavailability of CYP3A substrates using a physiologically-based pharmacokinetic model [O] . Olivares-Morales, Andrés, Kamiyama, Yoshiteru, Darwich, Adam S, 2015

机译：使用基于生理学的药代动力学模型分析控释制剂对口服药物吸收，肠壁代谢和CYp3a底物相对生物利用度的影响
8. A Physiologically-based Pharmacokinetic and Pharmacodynamic Model for the Oral Dosing of Rats with Ethyl Acrylate and Its Implications for Risk Assessment (paper Preprint) W-letter. [R] . 1992

机译：基于生理学的药代动力学和药效学模型，用于口服丙烯酸乙酯大鼠及其对风险评估的影响（纸质预印本）W字母。

Application of Physiologically-Based Oral Absorption & Pharmacokinetic Modeling to Investigate Formulation Factors Influencing the Pharmacokinetics of Novel Oral Anticoagulants

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