Promotion of osteogenesis by bioactive glass-ceramic coating: Possible involvement of the Hedgehog signaling pathway

摘要

Purpose: Bioactive glasseceramic (BGC) coatings have been extensively studied and clinically used as bone substitute materials because of their osteogenesis, osteoinduction, and osteoconduction characteristics. Although the Hedgehog (Hh) signaling pathway plays an important role in skeletal development, the relationship between BGC coatings and the Hh signaling pathway is unknown.