Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes

Jabbari Edwin; Woodside John; Guo Tong; Magdalinou Nadia K.; Chelban Viorica; Athauda Dilan; Lees Andrew J.; Foltynie Thomas; Houlden Henry; Church Alistair; Hu Michele T. M.; Rowe James B.; Zetterberg Henrik; Morris Huw R.

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Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes

机译：接近延伸测定测试揭示了非典型帕金森综合征的新型诊断生物标志物

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Objective The high degree of clinical overlap between atypical parkinsonian syndromes (APS) and Parkinson's disease (PD) makes diagnosis challenging. We aimed to identify novel diagnostic protein biomarkers of APS using multiplex proximity extension assay (PEA) testing.

机译：目的，非典型帕金森综合征（APS）和帕金森病（PD）之间的高度临床重叠使诊断具有挑战性。我们旨在使用多路复用接近延伸测定（PEA）测试来识别APS的新型诊断蛋白生物标志物。

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《Journal of Neurology, Neurosurgery and Psychiatry》 |2019年第7期|共6页
作者
Jabbari Edwin; Woodside John; Guo Tong; Magdalinou Nadia K.; Chelban Viorica; Athauda Dilan; Lees Andrew J.; Foltynie Thomas; Houlden Henry; Church Alistair; Hu Michele T. M.; Rowe James B.; Zetterberg Henrik; Morris Huw R.;
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作者单位

UCL UCL Queen Sq Inst Neurol Dept Clin &

Movement Neurosci London WC1N 3BG England;

UCL UCL Queen Sq Inst Neurol Dept Clin &

Movement Neurosci London WC1N 3BG England;

UCL UCL Queen Sq Inst Neurol Dept Clin &

Movement Neurosci London WC1N 3BG England;

UCL UCL Queen Sq Inst Neurol Reta Lila Weston Inst London England;

UCL UCL Queen Sq Inst Neurol Dept Clin &

Movement Neurosci London WC1N 3BG England;

UCL UCL Queen Sq Inst Neurol Dept Clin &

Movement Neurosci London WC1N 3BG England;

UCL UCL Queen Sq Inst Neurol Reta Lila Weston Inst London England;

UCL UCL Queen Sq Inst Neurol Dept Clin &

Movement Neurosci London WC1N 3BG England;

UCL UCL Queen Sq Inst Neurol Dept Clin &

Movement Neurosci London WC1N 3BG England;

Royal Gwent Hosp Dept Neurol Newport Shrops England;

Univ Oxford Nuffield Dept Clin Neurosci Oxford England;

Univ Oxford MRC Cognit &

Brain Sci Unit Oxford England;

UCL UCL Queen Sq Inst Neurol Dept Neurodegenerat Dis London England;

UCL UCL Queen Sq Inst Neurol Dept Clin &

Movement Neurosci London WC1N 3BG England;

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正文语种 eng
中图分类神经病学;
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1. Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes [J] . Jabbari Edwin, Woodside John, Guo Tong, Journal of Neurology, Neurosurgery and Psychiatry . 2019,第7期

机译：接近延伸测定测试揭示了非典型帕金森综合征的新型诊断生物标志物
2. Using proximity extension proteomics assay to discover novel biomarkers associated with circulating leptin levels in patients with type 2 diabetes [J] . Camilla Vavruch, C. Nowak, T. Feldreich, Scientific reports. . 2020,第1期

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3. Monitoring of Protein Biomarkers of Inflammation in Human Traumatic Brain Injury Using Microdialysis and Proximity Extension Assay Technology in Neurointensive Care [J] . Dyhrfort Philip, Shen Qiujin, Clausen Fredrik, Journal of neurotrauma . 2019,第20期

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4. Robotic assay of arm reaching movements in diverse neurologic populations: Can movement features be reliable, disease-specific diagnostic biomarkers? [C] . Kang Christine Y., Conroy Susan S., Roy Anindo, Proceedings of the IEEE/RAS-EMBS International Conference on Rehabilitation Robotics . 2015

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5. Gonadal intersex in teleosts: Mechanisms, molecular biomarkers and diagnostic assays [D] . Abdel-moneim Mohamed, Ahmed M. E. 2016

机译：硬骨鱼类中的性腺性交：机制，分子生物标志物和诊断分析
6. Research paper: Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes [O] . Edwin Jabbari, John Woodside, Tong Guo, -1

机译：研究论文：接近扩展分析测试揭示了非典型帕金森综合征的新型诊断生物标志物
7. Usefulness of Cardiac MIBG Scintigraphy, Olfactory Testing and Substantia Nigra Hyperechogenicity as Additional Diagnostic Markers for Distinguishing between Parkinson's Disease and Atypical Parkinsonian Syndromes. [O] . Hiroaki Fujita, Keisuke Suzuki, Ayaka Numao, 2016

机译：心脏mIBG闪烁扫描，嗅觉测试和黑质高回原性作为区分帕金森病和非典型帕金森病综合征的其他诊断标记的有用性。

Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes

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