Therapies for Children with Autism Spectrum Disorders

摘要

What are the effectiveness, benefits, and harms of therapies used to address core and associated symptoms of autism spectrum disorders (ASDs) in children two to 12 years of age?Medical intervention with risperidone (Ris-perdal) or aripiprazole (Abilify) has shown benefit for reducing challenging behaviors in some children with ASDs. However, adverse effects, including weight gain, sedation, and extrapyramidal effects, are significant. Multiple randomized controlled trials of secretin demonstrated no benefit. There is insufficient evidence regarding benefits or adverse effects of other medical treatments, including selective serotonin reuptake inhibitors and stimulant medications. Some behavioral interventions are associated with positive outcomes in certain children, but it is not clear which children are most likely to respond to specific interventions.