Do Resistin and Tumor Necrosis Factor-a Relate to Changes in Insulin Resistance in Normal Pregnancy?

摘要

Problem statement: The purpose of this study was to evaluate the role of resistin and Tumor Necrosis Factor-a (TNF-alpha) in insulin resistance during pregnancy. Approach: Serum resistin and TNF-a concentrations were measured by ELISA in 86 healthy pregnant women (26, 23 and 37 of them in the 1 st, 2nd and 3rd trimesters, respectively) and in 21 healthy non pregnant women in a cross sectional study. Results: Resistin concentration was significantly higher in the third trimester (9.5+-3.3 ng mL~(-1))as compared with non pregnant women (7+-3.3 ng mL~(-1)). Serum TNF-a level were also significantly increase in pregnant women (2.6+-1.9 pg mL~(-1)) as compared with maternal healthy controls (0.8 +-0.7 pg mL~(-1)). There were significant correlation between gestational age and BMI (r = 0.28, p = 0.01), resistin (r = 0.36, p = 0.002) and TNF-a (r = -0.44, p<0.0001). There was not significant correlation between gestational age and Insulin Resistance (IR). We also did not found correlation between IR andresistin as well as between IR and TNF-a in pregnant women. Conclusion: TNF-a and resistin do not appear to contribute greatly to pregnancy induced insulin resistance in healthy pregnancy.