Multiflorumisides A–G, Dimeric Stilbene Glucosides with Rare Coupling Patterns from the Roots of i>Polygonum multiflorum/i>

摘要

Multiflorumisides A–G ( 1 – 7 ), seven new dimeric stilbene glucosides with two rare coupling patterns, were isolated from the roots of Polygonum multiflorum . The structures of these new dimeric stilbene glucosides were elucidated through comprehensive spectroscopic and chemical analyses. The absolute configurations of 3 and 5 – 7 were established by comparing their experimental and quantum-chemical ECD data. Putative biosynthetic pathways toward the dimers and their suppressive effects against nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells are also discussed.