Is genetic testing for cytochrome P450 polymorphisms ready for implementation?

摘要

Individual variation in response to drugs is a problem that physicians routinely face in clinical practice. Such variation can result in lack of anticipated response, serious adverse drug reactions, or unexpected drug interactions in patients receiving multiple medications. In this issue of AFP, Lynch and Price review the clinical effects of cytochrome P450 (CYP450) metabolism on drug response, adverse effects, and interactions.