Antidepressants for the Treatment of Neuropathic Pain

摘要

Clinical Scenario A 70-year-old man with a long-standing history of poorly controlled type 2 diabetes presents with increasing burning and tingling in his feet.Should antidepressants be used for the treatment of neuropathic pain?Tricyclic antidepressants, particularly ami-triptyline, are effective for the treatment of painful diabetic neuropathy and postherpetic neuralgia, and may be beneficial in other neuropathic pain syndromes, but they should be used with caution in patients at increased risk of adverse events.