Facile and versatile solid state surface modification of silk fibroin membranes using click chemistry

摘要

Reported is a fast and versatile protocol to surface modify pre-cast silk membranes targeting tyrosine residues. Enriched alkyne silk membranes were prepared using this method and azides possessing a range of functional groups were tethered to the membrane surface using click chemistry to give a range of water contact angles from 85 +/- 3 degrees to 34 +/- 6 degrees.