Effectiveness of antidepressants compared with placebo for depression in primary care.

摘要

What is the effectiveness of antidepressants compared with placebo for the treatment of depression in primary care settings? Tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) are more effective than placebo for the treatment of depression in primary care settings. (Strength of Recommendation = A, based on consistent, good-quality patient-oriented evidence)