BIOKINETIC MODEL OF Tc-99m MIBI FOR EIGHT PATIENTS UNDERGONE MYOCARDIAL PERFUSION EXAMINATION via GAMMA CAMERA AND MATLAB PROGRAM: AN IN-VIVO STUDY

摘要

Biokinetic model of Tc-99m MIBI for eight patients undergone myocardial perfusion examination was studied using gamma camera and MATLAB program. A six-compartment model was adopted to interpret the metabolic mechanism of each patient. Within the model framework, the respective set of simultaneous differential equations was solved by a self-developed program run in MATLAB.?The experimental results exhibited a good fit with the theoretical predictions via the model. The average biological half-lives of body fluid, heart, thyroid, liver, GI Tract and remainder were assessed as 3.3±1.1, 0.6±0.3, 0.2±0.2, 11.7±0.0, 0.4±0.2, and 18.3±1.1h, respectively. A dimensionless AT index of disagreement between the experimental data and MATLAB optimal solution was proposed of validating the applied acquisition system and analytical method feasibility. An AT of zero implies a perfect agreement between the theoretical and empirical results, while averages of the derived AT were fluctuated from 3 ± 2 to 25±18 for five compartments. The proposed refined equation estimated the internal dose from gamma-ray as 3.38±2.58mSv for eight patients according to a fast screening method, which defined human body as a spherical ball to simplify the calculation in reality. The proposed MATLAB-based fitting of in-vivo data with the theoretical results was instrumental for assessing the radiation dose received by the Tc-99m MIBI scan participants.