A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium

Noordam Raymond; Sitlani Colleen M.; Avery Christy L.; Stewart James D.; Gogarten Stephanie M.; Wiggins Kerri L.; Trompet Stella; Warren Helen R.; Sun Fangui; Evans Daniel S.; Li Xiaohui; Li Jin; Smith Albert V.; Bis Joshua C.; Brody Jennifer A.; Busch Evan L.; Caulfield Mark J.; Chen Yii-Der I.; Cummings Steven R.; Cupples L. Adrienne; Duan Qing; Franco Oscar H.; Mendez-Giraldez Raul; Harris Tamara B.; Heckbert Susan R.; van Heemst Diana; Hofman Albert; Floyd James S.; Kors Jan A.; Launer Lenore J.; Li Yun; Li-Gao Ruifang; Lange Leslie A.; Lin Henry J.; de Mutsert Renee; Napier Melanie D.; Newton-Cheh Christopher; Poulter Neil; Reiner Alexander P.; Rice Kenneth M.; Roach Jeffrey; Rodriguez Carlos J.; Rosendaal Frits R.; Sattar Naveed; Sever Peter; Seyerle Amanda A.; Slagboom P. Eline; Soliman Elsayed Z.; Sotoodehnia Nona; Stott David J.; Stumer Til; Taylor Kent D.; Thornton Timothy A.; Uitterlinden Andre G.; Wilhelmsen Kirk C.; Wilson James G.; Gudnason Vilmundur; Jukema J. Wouter; Laurie Cathy C.; Liu Yongmei; Mook-Kanamori Dennis O.; Munroe Patricia B.; Rotter Jerome I.; Vasan Ramachandran S.; Psaty Bruce M.; Stricker Bruno H.; Whitsel Eric A.

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A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium

机译：三环/四环抗抑郁药和RR和QT间隔的基因组相互作用分析：基因组流行病学（电荷）联盟中心脏病和老化研究队列的药物族学研究

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Background Increased heart rate and a prolonged QT interval are important risk factors for cardiovascular morbidity and mortality, and can be influenced by the use of various medications, including tricyclic/tetracyclic antidepressants (TCAs). We aim to identify genetic loci that modify the association between TCA use and RR and QT intervals.

机译：背景技术心率提高，延长的QT间隔是心血管发病率和死亡率的重要危险因素，并且可以受到各种药物的使用，包括三环/四环抗抑郁药（TCAS）。我们的目标是识别修改TCA使用与RR和QT间隔之间的关联的遗传基因座。

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《Journal of Medical Genetics》 |2017年第5期|共11页
作者
Noordam Raymond; Sitlani Colleen M.; Avery Christy L.; Stewart James D.; Gogarten Stephanie M.; Wiggins Kerri L.; Trompet Stella; Warren Helen R.; Sun Fangui; Evans Daniel S.; Li Xiaohui; Li Jin; Smith Albert V.; Bis Joshua C.; Brody Jennifer A.; Busch Evan L.; Caulfield Mark J.; Chen Yii-Der I.; Cummings Steven R.; Cupples L. Adrienne; Duan Qing; Franco Oscar H.; Mendez-Giraldez Raul; Harris Tamara B.; Heckbert Susan R.; van Heemst Diana; Hofman Albert; Floyd James S.; Kors Jan A.; Launer Lenore J.; Li Yun; Li-Gao Ruifang; Lange Leslie A.; Lin Henry J.; de Mutsert Renee; Napier Melanie D.; Newton-Cheh Christopher; Poulter Neil; Reiner Alexander P.; Rice Kenneth M.; Roach Jeffrey; Rodriguez Carlos J.; Rosendaal Frits R.; Sattar Naveed; Sever Peter; Seyerle Amanda A.; Slagboom P. Eline; Soliman Elsayed Z.; Sotoodehnia Nona; Stott David J.; Stumer Til; Taylor Kent D.; Thornton Timothy A.; Uitterlinden Andre G.; Wilhelmsen Kirk C.; Wilson James G.; Gudnason Vilmundur; Jukema J. Wouter; Laurie Cathy C.; Liu Yongmei; Mook-Kanamori Dennis O.; Munroe Patricia B.; Rotter Jerome I.; Vasan Ramachandran S.; Psaty Bruce M.; Stricker Bruno H.; Whitsel Eric A.;
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作者单位

Univ Med Ctr Rotterdam Erasmus MC Dept Epidemiol POB 2040 NL-3000 CA Rotterdam Netherlands;

Univ Washington Dept Med Seattle WA USA;

Univ N Carolina Dept Epidemiol Chapel Hill NC USA;

Univ N Carolina Dept Epidemiol Chapel Hill NC USA;

Univ Washington Dept Biostat Seattle WA 98195 USA;

Univ Washington Dept Med Seattle WA USA;

Leiden Univ Med Ctr Sect Gerontol &

Geriatr Dept Internal Med Leiden Netherlands;

Queen Mary Univ London Barts &

London Sch Med Dept Clin Pharmacol William Harvey Res Inst;

Boston Univ Sch Publ Hlth Dept Biostat Boston MA USA;

Calif Pacific Med Ctr Res Inst San Francisco CA USA;

Harbor UCLA Med Ctr Los Angeles Biomed Res Inst Inst Translat Genom &

Populat Sci Torrance CA;

Stanford Univ Sch Med Dept Med Div Cardiovasc Med Palo Alto CA 94304 USA;

Iceland Heart Assoc Kopavogur Iceland;

Univ Washington Dept Med Seattle WA USA;

Univ Washington Dept Med Seattle WA USA;

Harvard TH Chan Sch Publ Hlth Dept Epidemiol Boston MA USA;

Queen Mary Univ London Barts &

London Sch Med Dept Clin Pharmacol William Harvey Res Inst;

Harbor UCLA Med Ctr Los Angeles Biomed Res Inst Inst Translat Genom &

Populat Sci Torrance CA;

Calif Pacific Med Ctr Res Inst San Francisco CA USA;

Boston Univ Sch Publ Hlth Dept Biostat Boston MA USA;

Univ N Carolina Dept Genet Chapel Hill NC USA;

Univ Med Ctr Rotterdam Erasmus MC Dept Epidemiol POB 2040 NL-3000 CA Rotterdam Netherlands;

Univ N Carolina Dept Epidemiol Chapel Hill NC USA;

NIA Lab Epidemiol Demog &

Biometry Bethesda MD 20892 USA;

Univ Washington Dept Epidemiol Seattle WA 98195 USA;

Leiden Univ Med Ctr Sect Gerontol &

Geriatr Dept Internal Med Leiden Netherlands;

Univ Med Ctr Rotterdam Erasmus MC Dept Epidemiol POB 2040 NL-3000 CA Rotterdam Netherlands;

Univ Washington Dept Med Seattle WA USA;

Univ Med Ctr Rotterdam Erasmus MC Dept Med Informat Rotterdam Netherlands;

NIA Lab Epidemiol Demog &

Biometry Bethesda MD 20892 USA;

Univ N Carolina Dept Genet Chapel Hill NC USA;

Leiden Univ Med Ctr Dept Clin Epidemiol Leiden Netherlands;

Univ N Carolina Dept Genet Chapel Hill NC USA;

Harbor UCLA Med Ctr Los Angeles Biomed Res Inst Inst Translat Genom &

Populat Sci Torrance CA;

Leiden Univ Med Ctr Dept Clin Epidemiol Leiden Netherlands;

Univ N Carolina Dept Epidemiol Chapel Hill NC USA;

Framingham Heart Dis Epidemiol Study Framingham MA USA;

Imperial Coll London Int Ctr Circulatory Hlth London England;

Univ Washington Dept Epidemiol Seattle WA 98195 USA;

Univ Washington Dept Biostat Seattle WA 98195 USA;

Univ N Carolina Res Comp Ctr Chapel Hill NC USA;

Wake Forest Sch Med Dept Med Winston Salem NC USA;

Leiden Univ Med Ctr Dept Clin Epidemiol Leiden Netherlands;

Imperial Coll London Int Ctr Circulatory Hlth London England;

Univ N Carolina Dept Epidemiol Chapel Hill NC USA;

BHF Glasgow Cardiovasc Res Ctr Fac Med Glasgow Lanark Scotland;

Wake Forest Sch Med Epidemiol Cardiol Res Ctr EPICARE Winston Salem NC USA;

Univ Washington Dept Med Seattle WA USA;

Univ Glasgow Inst Cardiovasc &

Med Sci Glasgow Lanark Scotland;

Univ N Carolina Dept Epidemiol Chapel Hill NC USA;

Harbor UCLA Med Ctr Los Angeles Biomed Res Inst Inst Translat Genom &

Populat Sci Torrance CA;

Univ Washington Dept Biostat Seattle WA 98195 USA;

Univ Med Ctr Rotterdam Erasmus MC Dept Internal Med Rotterdam Netherlands;

Univ N Carolina Dept Genet Chapel Hill NC USA;

Univ Mississippi Med Ctr Dept Physiol &

Biophys Jackson MS 39216 USA;

Iceland Heart Assoc Kopavogur Iceland;

Leiden Univ Med Ctr Dept Cardiol Leiden Netherlands;

Univ Washington Dept Biostat Seattle WA 98195 USA;

Wake Forest Univ Dept Epidemiol &

Prevent Div Publ Hlth Sci Winston Salem NC 27109 USA;

Leiden Univ Med Ctr Sect Gerontol &

Geriatr Dept Internal Med Leiden Netherlands;

Queen Mary Univ London Barts &

London Sch Med Dept Clin Pharmacol William Harvey Res Inst;

Harbor UCLA Med Ctr Los Angeles Biomed Res Inst Inst Translat Genom &

Populat Sci Torrance CA;

Framingham Heart Dis Epidemiol Study Framingham MA USA;

Univ Washington Dept Med Seattle WA USA;

Univ Med Ctr Rotterdam Erasmus MC Dept Epidemiol POB 2040 NL-3000 CA Rotterdam Netherlands;

Univ N Carolina Dept Epidemiol Chapel Hill NC USA;

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正文语种 eng
中图分类医学遗传学;
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1. A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium [J] . Noordam Raymond, Sitlani Colleen M., Avery Christy L., Journal of Medical Genetics . 2017,第5期

机译：三环/四环抗抑郁药和RR和QT间隔的基因组相互作用分析：基因组流行病学（电荷）联盟中心脏病和老化研究队列的药物族学研究
2. A Genome-Wide Association Study for Venous Thromboembolism: The Extended Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium [J] . TangW., TeichertM., ChasmanD.I., Genetic epidemiology. . 2013,第5期

机译：静脉血栓栓塞症的全基因组关联研究：基因流行病学（CHARGE）联盟的心脏和衰老研究的扩展队列
3. A Meta-analysis of Four Genome-Wide Association Studies of Survival to Age 90 Years or Older: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium [J] . Anne B. Newman, Stefan Walter, Kathryn L. Lunetta, The journals of gerontology.Series A. Biological sciences and medical sciences . 2010,第5期

机译：对生存至90岁或更老的四个全基因组关联研究的荟萃分析：基因组流行病学联盟的心脏和衰老研究队列
4. Systematic methods for fetal electrocardiographic analysis: Determining the fetal heart rate, RR interval and QT interval [C] . Liu Chengyu, Li Peng Computing in Cardiology Conference . 2013

机译：胎儿心电图分析的系统方法：确定胎儿心率，RR间隔和QT间隔
5. An interaction between statins and clopidogrel---A pharmacoepidemiology cohort study with survival time analysis. [D] . Blagojevic, Ana. 2008

机译：他汀类药物与氯吡格雷之间的相互作用-一项具有生存时间分析的药物流行病学队列研究。
6. A genome-wide interaction analysis of tri/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium [O] . Raymond Noordam, Colleen M Sitlani, Christy L Avery, -1

机译：三环/四环抗抑郁药以及RR和QT区间的全基因组相互作用分析：一项来自基因组流行病学（CHARGE）联盟心脏和衰老研究小组的药物基因组学研究
7. A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium [O] . Noordam, R, Sitlani, CM, Avery, CL, 2016

机译：三环/四环类抗抑郁药与RR和QT间期的全基因组相互作用分析：来自基因组流行病学（CHaRGE）联盟的心脏和衰老研究组的药物基因组学研究

A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium

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