Optimization of Lu-177-labeled GRPR antagonist PEG2-RM26 for GRPR-targeted radiotherapy: Influence of chelator on labeling, stability, and biodistribution

Mitran Bogdan; Rinne Sara; Konijnenberg Mark; Maina Theodosia; Nock Berthold A.; Altai Mohamed; Vorobyeva Anzhelika; Larhed Mats; Tolmachev Vladimir; De Jong Marion; Rosenstrom Ulrika; Orlova Anna

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Optimization of Lu-177-labeled GRPR antagonist PEG2-RM26 for GRPR-targeted radiotherapy: Influence of chelator on labeling, stability, and biodistribution

机译：Lu-177标记的GRPR拮抗剂PEG2-RM26的优化用于GRPR靶向放射治疗：螯合剂对标签，稳定性和生物分布的影响

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《Journal of Labelled Compounds and Radiopharmaceuticals》 |2019年第s1期|共3页
作者
Mitran Bogdan; Rinne Sara; Konijnenberg Mark; Maina Theodosia; Nock Berthold A.; Altai Mohamed; Vorobyeva Anzhelika; Larhed Mats; Tolmachev Vladimir; De Jong Marion; Rosenstrom Ulrika; Orlova Anna;
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作者单位

Uppsala Univ Uppsala Sweden;

Uppsala Univ Uppsala Sweden;

Erasmus MC Rotterdam Netherlands;

NCSR Demokritos IR RP Athens Greece;

Uppsala Univ Uppsala Sweden;

Uppsala Univ Uppsala Sweden;

Uppsala Univ Dept Med Chem Sci Life Lab Uppsala Sweden;

Uppsala Univ Uppsala Sweden;

Erasmus MC Rotterdam Netherlands;

Uppsala Univ Uppsala Sweden;

Uppsala Univ Uppsala Sweden;

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正文语种 eng
中图分类药学;
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1. Optimization of Lu-177-labeled GRPR antagonist PEG2-RM26 for GRPR-targeted radiotherapy: Influence of chelator on labeling, stability, and biodistribution [J] . Mitran Bogdan, Rinne Sara, Konijnenberg Mark, Journal of Labelled Compounds and Radiopharmaceuticals . 2019,第S1期

机译：Lu-177标记的GRPR拮抗剂PEG2-RM26的优化用于GRPR靶向放射治疗：螯合剂对标签，稳定性和生物分布的影响
2. Comparative cell uptake study of FITC-/Lu-177-labeled RM26 monomer, dimer and trimer on PC-3: improving binding affinity of gastrin releasing peptide receptor (GRPR) antagonist via bivalency/trivalency [J] . Zhuo Liangang, Yang Xia, Liao Wei, Journal of Radioanalytical and Nuclear Chemistry: An International Journal Dealing with All Aspects and Applications of Nuclear Chemistry . 2019,第3期

机译：FITC-/ Lu-177标记的RM26单体，二聚体和三聚体对PC-3的比较细胞摄取研究：通过偶然/三价地改善胃泌素释放肽受体（GRPR）拮抗剂的结合亲和力
3. Selection of an optimal macrocyclic chelator improves the imaging of prostate cancer using cobalt-labeled GRPR antagonist RM26 [J] . Bogdan Mitran, Helge Thisgaard, Sara Rinne, Scientific reports. . 2019,第1期

机译：选择最佳的宏环螯合剂使用钴标记的GRPR拮抗剂RM26改善前列腺癌的成像
4. Numerical simulation and design optimization research of slope ratio and platforms influence on a high rock cut slope engineering stability [C] . Lei He, Yan Ren, Zixia Feng Global Conference on Civil, Structural and Environmental Engineering . 2015

机译：坡度比和平台对高岩石斜坡工程稳定性影响的数值模拟与设计优化研究
5. In Vitro and In Vivo Evaluation of a 18F-Labeled High Affinity NOTA Conjugated Bombesin Antagonist as a PET Ligand for GRPR-Targeted Tumor Imaging [O] . Zohreh Varasteh, Ola Åberg, Irina Velikyan, -1

机译：体外和体内评估的18F标签的高亲和力NOTA共轭的Bombesin拮抗剂作为用于GRPR靶向肿瘤成像的PET配体
6. In Vitro and In Vivo Evaluation of a F-18-Labeled High Affinity NOTA Conjugated Bombesin Antagonist as a PET Ligand for GRPR-Targeted Tumor Imaging [O] . Varasteh, Zohreh, Åberg, Ola, Velikyan, Irina, 2013

机译：F-18标签的高亲和力NOTA共轭的薄壁蛋白拮抗剂作为PET配体的体外和体内评估，用于GRPR靶向肿瘤成像

Optimization of Lu-177-labeled GRPR antagonist PEG2-RM26 for GRPR-targeted radiotherapy: Influence of chelator on labeling, stability, and biodistribution

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