Synthesis of C-14 labeled GABAA alpha 2/alpha 3 selective partial agonists and the investigation of late-occurring and long-circulating metabolites of GABAA receptor modulator AZD7325

Artelsmair Markus; Gu Chungang; Lewis Richard; Chapdelaine Marc; Elmore Charles S.

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Synthesis of C-14 labeled GABAA alpha 2/alpha 3 selective partial agonists and the investigation of late-occurring and long-circulating metabolites of GABAA receptor modulator AZD7325

机译：C-14的合成标记为GabaAα2/α3选择性局部激动剂和GABAA受体调节剂AZD7325的后期发生和长循环代谢物的研究

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《Journal of Labelled Compounds and Radiopharmaceuticals》 |2018年第14期|共1页
作者
Artelsmair Markus; Gu Chungang; Lewis Richard; Chapdelaine Marc; Elmore Charles S.;
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作者单位

AstraZeneca Innovat Med &

Early Clin Dev Molndal Sweden;

AstraZeneca Innovat Med &

Early Clin Dev Waltham MA USA;

AstraZeneca Innovat Med &

Early Clin Dev Molndal Sweden;

AstraZeneca Legacy R&

D Wilmington Wilmington DE USA;

AstraZeneca Innovat Med &

Early Clin Dev Molndal Sweden;

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原文格式 PDF
正文语种 eng
中图分类药学;
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入库时间 2022-08-20 09:30:08

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1. Synthesis of C-14 labeled GABAA alpha 2/alpha 3 selective partial agonists and the investigation of late-occurring and long-circulating metabolites of GABAA receptor modulator AZD7325 [J] . Artelsmair Markus, Gu Chungang, Lewis Richard, Journal of Labelled Compounds and Radiopharmaceuticals . 2018,第14期

机译：C-14的合成标记为GabaAα2/α3选择性局部激动剂和GABAA受体调节剂AZD7325的后期发生和长循环代谢物的研究
2. Late-occurring and Long-circulating Metabolites of GABA(A alpha 2,3) Receptor Modulator AZD7325 Involving Metabolic Cyclization and Aromatization: Relevance to MIST Analysis and Application for Patient Compliance [J] . Gu Chungang, Artelsmair Markus, Elmore Charles S., Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2018,第3期

机译：GABA（α2,3）受体调节剂AZD7325的后期发生和长循环代谢物涉及代谢环化和芳族化：与雾分析和患者遵守的应用相关性
3. GABAA receptor subtype-selective modulators. I. alpha2/alpha3-selective agonists as non-sedating anxiolytics. [J] . Atack JR Current topics in medicinal chemistry . 2011,第9期

机译：GABAA受体亚型选择性调节剂。 I.α2/α3-选择性激动剂作为非镇静抗焦虑药。
4. Design and Synthesis of Novel D-Azasteroid Analogues as Modulators of GABAA Receptor [C] . Yuefei Hu Proceedings of the First China-Korea symposium on organic chemistry . 2001

机译：新型D-氮杂甾体类似物作为GABAA受体调节剂的设计与合成
5. GABAA Receptors and Tonic Inhibition: Towards an Improved Understanding of Agonist Binding and in vivo Expression of the Extrasynaptic alpha 4beta3delta Subtype. [D] . Nilsson, Benjamin Gene. 2013

机译：GABAA受体和补品抑制：促进对激动剂结合和突触外α4beta3delta亚型的体内表达的更好的了解。
6. Synthesis of C‐14 labeled GABAA α2/α3 selective partial agonists and the investigation of late‐occurring and long‐circulating metabolites of GABAA receptor modulator AZD7325 [O] . Markus Artelsmair, Chungang Gu, Richard J. Lewis, -1

机译：C-14标记的GABAAα2/α3选择性部分激动剂的合成以及GABAA受体调节剂AZD7325的晚发生和长循环代谢产物的研究
7. Synthesis of C-14 labeled GABAAα2/α3 selective partial agonists and the investigation of late-occurring and long-circulating metabolites of GABAAreceptor modulator AZD7325 [O] . Markus Artelsmair, Chungang Gu, Richard J. Lewis, 2018

机译：C-14标记的GabaAα2/α3选择性局部激动剂的合成以及GabaeCeptor调节剂AZD7325的晚期发生和长循环代谢物的研究

Synthesis of C-14 labeled GABAA alpha 2/alpha 3 selective partial agonists and the investigation of late-occurring and long-circulating metabolites of GABAA receptor modulator AZD7325

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