First synthesis of (1,3,5-~(13)C_3)gallic acid

摘要

Gallic acid is a phenolic plant metabolite which is normally encountered in plant tissues in ester form. These esters include a group of catechins with antioxidant properties which are found in green tea. Epigallocatechin-3-gallate is the most abundant catechin in green tea and has been shown to inhibit carcinogenesis.~(1,2) An efficient and high-yielding synthesis for [1,3,5-~(13)C_3]gallic acid from non-aromatic precursors is presented. This will allow compounds such as gallic acid and its derivatives to be used as internal standards for analysis by LC-MS or GC-MS techniques.