PRODUCTION OF ~(177)Lu AND PRESENT STATUS OF ~(177)Lu BASED RADIOPHARMACEUTICALS IN INDIA

摘要

~(177)Lu is a potential radionuclide for the development of a wide variety of radiotherapeutic agents owing to its suitable nuclear decay characteristics, comparatively longer half-life and easy production using medium flux research reactors. Radiopharmaceuticals Division (RPhD), BARC has done pioneering work in the field of production of high specific activity ~(177)Lu and development of ~(177)Lu based agents for targeted radiotherapy and palliative care. Two of the agents, namely ~(177)Lu-EDTMP and ~(177)Lu-DOTA-TATE developed in RPhD, BARC are presently undergoing evaluation in human patients at different nuclear medicine centers across the country. More than 250 patients suffering from various kinds of cancers have been benefitted from these therapies.