Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers

Everts Richard J.; Begg Ronald; Gardiner Sharon J.; Zhang Mei; Turnidge John; Chambers Stephen T.; Begg Evan J.

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Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers

机译：对健康志愿者的氟氯苄三种药代动力学和药效学的丙烯酸和食物作用

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摘要

Objectives: To measure the effect of probenecid, fasting and fed, on flucloxacillin pharmacokinetic and pharmacodynamic endpoints.

机译：目的：测量丙烯酸，禁食和喂养的效果，对氟脲氧基林药代动力学和药效学终点。

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来源
《Journal of Infection》 |2020年第1期|共12页
作者
Everts Richard J.; Begg Ronald; Gardiner Sharon J.; Zhang Mei; Turnidge John; Chambers Stephen T.; Begg Evan J.;
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作者单位

Nelson Hosp Dept Med Nelson New Zealand;

Univ Otago Christchurch Dept Med Christchurch New Zealand;

Christchurch Hosp Dept Infect Dis Christchurch New Zealand;

Univ Otago Christchurch Dept Med Christchurch New Zealand;

Univ Adelaide Dept Pathol Adelaide SA Australia;

Christchurch Hosp Dept Infect Dis Christchurch New Zealand;

Univ Otago Christchurch Dept Med Christchurch New Zealand;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
Flucloxacillin; Probenecid; Food; Pharmacokinetics;

机译：Flycloxacillin;probenecid;食物;药代动力学;

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专利

1. Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers [J] . Everts Richard J., Begg Ronald, Gardiner Sharon J., Journal of Infection . 2020,第1期

机译：对健康志愿者的氟氯苄三种药代动力学和药效学的丙烯酸和食物作用
2. Studies on interactions between functional foods or dietary supplements and medicines. IV. Effects of ginkgo biloba leaf extract on the pharmacokinetics and pharmacodynamics of nifedipine in healthy volunteers. [J] . Yoshioka M, Ohnishi N, Koishi T, Biological & pharmaceutical bulletin . 2004,第12期

机译：研究功能食品或膳食补充剂与药物之间的相互作用。 IV。银杏叶提取物对硝苯地平在健康志愿者体内的药代动力学和药效学的影响。
3. Effects of food on the single-dose pharmacokinetics/pharmacodynamics of tizanidine capsules and tablets in healthy volunteers. [J] . Shah J, Wesnes KA, Kovelesky RA, Clinical therapeutics . 2006,第9期

机译：食物对健康志愿者中替扎尼定胶囊和片剂的单剂量药代动力学/药效学的影响。
4. Safety, tolerability, pharmacodynamics and pharmacokinetics following single subcutaneous dosesof a teverelix depot formulation in healthy male volunteers [C] . C. MacLean, F. Larsen, R. Piechatzek, Annual meeting exposition of the Controlled Release Society . 2005

机译：在健康男性志愿者中单次皮下注射Teverelix储库制剂后的安全性，耐受性，药效动力学和药代动力学
5. Propafenone pharmacokinetics: GLC-ECD analysis; metabolic induction by phenobarbital in nonsmoking and smoking healthy volunteers; protein binding; pharmacodynamics in patients [D] . Chan, Grace Lap-Yu 1989

机译：普罗帕酮药代动力学：GLC-ECD分析；非吸烟和吸烟健康志愿者的苯巴比妥诱导代谢；蛋白质结合；患者的药效学
6. Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers [O] . Yi-fan Zhang, Xiao-jian Dai, Yong Yang, 2016

机译：丙磺舒和西咪替丁对健康中国志愿者奈莫沙星药代动力学的影响
7. Studies on Interactions between Functional Foods or Dietary Supplements and Medicines. IV. Effects of Ginkgo biloba Leaf Extract on the Pharmacokinetics and Pharmacodynamics of Nifedipine in Healthy Volunteers [O] . Mutsunobu Yoshioka, Noriaki Ohnishi, Tomokazu Koishi, 2004

机译：功能性食品或膳食补充剂和药物之间相互作用的研究。 IV。银杏叶叶提取物对健康志愿者硝苯地平药代动力学和药效学的影响

Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers

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