Isatin-Coumarin Hybrids Tethered via Diethylene Glycol: Design, Synthesis, and Their In Vitro Antitumor Activities

摘要

A series of novel isatin-coumarin hybrids was designed, synthesized, and assessed for their in vitro antitumor activities against drug-sensitive HepG2, Hela, A549, DU145 (prostatic cancer), SKOV3, and MCF-7 as well as drug-resistant MCF-7/DOX (doxorubicin-resistant MCF-7) human cancer cell lines. Results revealed that the synthesized hybrids displayed considerable activities against the tested seven cancer cell lines.