USE OF THROMBOCYTE-LEUKOCYTE-RICH PLASMA IN THE TREATMENT OF CHRONIC ORAL CAVITY DISORDERS IN REPTILES: TWO CASE REPORTS

摘要

Regenerative medicine has gained a strong interest in reptile practice, with transposition of techniques widely used in human and mammal medicine. Specifically, Platelet Rich Plasma (PRP) and derived products have shown to be safe and promising tools to improve soft and bone tissue healing in this class. Hereby we present two cases of oral cavity disorders treated with heterologous Thrombocyte-Leukocyte Rich Plasma (TLRP). In the first case, TLRP was used on one ball python (Python regius) with chronic facial cellulitis, to adjuvate post-surgical wound healing. In the second case, it was the elected therapy to treat one veiled chameleon (Chamaeleo calyptratus) with severe maxillary osteolysis secondary to chronic periodontal disease. Repeated CT scans were performed to evaluate healing progression. In both cases, single administration of TLRP was able to stop bone lysis progression, but was not enough to promote new bone formation. Our experience suggests that the use of thrombocyte-derived products, thanks to their regenerative and antimicrobial properties, could represent a useful tool to adjuvate traditional therapies in reptile reconstructive medicine. Copyright 2018 Elsevier Inc. All rights reserved.