Comparative inhibition of tetrameric carbonyl reductase activity in pig heart cytosol by alkyl 4-pyridyl ketones

Shimada Hideaki; Tanigawa Takahiro; Matayoshi Kazunori; Katakura Kazufumi; Babazono Ken; Takayama Hiroyuki; Murahashi Tsuyoshi; Akita Hiroyuki; Higuchi Toshiyuki; Eto Masashi; Imamura Yorishige

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Comparative inhibition of tetrameric carbonyl reductase activity in pig heart cytosol by alkyl 4-pyridyl ketones

机译：烷基4-吡啶基酮猪心脏细胞溶胶中四聚羰基还原酶活性的比较抑制

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摘要

Context and objective: The present study is to elucidate the comparative inhibition of tetrameric carbonyl reductase (TCBR) activity by alkyl 4-pyridyl ketones, and to characterize its substrate-binding domain.

机译：背景和目的：本研究是阐明烷基4-吡啶基酮的四聚羰基还原酶（TCBR）活性的比较抑制，并表征其基质结合结构域。

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来源
《Journal of enzyme inhibition and medicinal chemistry.》 |2014年第6期|共4页
作者
Shimada Hideaki; Tanigawa Takahiro; Matayoshi Kazunori; Katakura Kazufumi; Babazono Ken; Takayama Hiroyuki; Murahashi Tsuyoshi; Akita Hiroyuki; Higuchi Toshiyuki; Eto Masashi; Imamura Yorishige;
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作者单位

Kumamoto Univ Fac Educ Chuo Ku Kumamoto 8608555 Japan;

Kumamoto Univ Fac Educ Chuo Ku Kumamoto 8608555 Japan;

Nihon Pharmaceut Univ Komuro Saitama Japan;

Nihon Pharmaceut Univ Komuro Saitama Japan;

Nihon Pharmaceut Univ Komuro Saitama Japan;

Nihon Pharmaceut Univ Komuro Saitama Japan;

Nihon Pharmaceut Univ Komuro Saitama Japan;

Nihon Pharmaceut Univ Komuro Saitama Japan;

Nihon Pharmaceut Univ Komuro Saitama Japan;

Sojo Univ Fac Pharmaceut Sci Nishi Ku Kumamoto Japan;

Nihon Pharmaceut Univ Komuro Saitama Japan;

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原文格式 PDF
正文语种 eng
中图分类酶;
关键词
4-Benzoylpyridine; 4-hexanoylpyridine; competitive inhibition; cyclohexyl pentyl ketone; stereoselective reduction;

机译：4-苯甲酰吡啶;4-己酰基吡啶;竞争抑制;环己基戊烯酮;立体选择性减少;

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专利

1. Comparative inhibition of tetrameric carbonyl reductase activity in pig heart cytosol by alkyl 4-pyridyl ketones [J] . Shimada Hideaki, Tanigawa Takahiro, Matayoshi Kazunori, Journal of enzyme inhibition and medicinal chemistry. . 2014,第1a6期

机译：烷基4-吡啶基酮比较抑制猪心胞液中四聚体羰基还原酶活性
2. Comparative inhibition of tetrameric carbonyl reductase activity in pig heart cytosol by alkyl 4-pyridyl ketones [J] . Hideaki Shimada, Takahiro Tanigawa, Kazunori Matayoshi, Journal of enzyme inhibition and medicinal chemistry. . 2014,第3期

机译：烷基4-吡啶基酮比较抑制猪心胞液中四聚体羰基还原酶活性
3. Comparative inhibition of tetrameric carbonyl reductase activity in pig heart cytosol by alkyl 4-pyridyl ketones [J] . Shimada Hideaki, Tanigawa Takahiro, Matayoshi Kazunori, Journal of enzyme inhibition and medicinal chemistry. . 2014,第1a6期

机译：烷基4-吡啶基酮猪心脏细胞溶胶中四聚羰基还原酶活性的比较抑制
4. HOW THE a-SUBSTITUTION OF SUBSTRATE AFFECTS THE SPECIFIC ACTIVITY AND STEREOSELECTIVIY OF CARBONYL REDUCTASE [C] . Xi Chen, Hongliu Zhang, Jinhui Feng, Enzyme Engineering Conference . 2018

机译：底物的替代如何影响羰基还原酶的特定活性和立体切性
5. Structure-activity studies of the inhibition of FabI, the enoyl ACP reductase from Escherichia coli by triclosan. [D] . Sivaraman, Sharada. 2002

机译：结构活性研究三氯生对FabI的抑制作用，FabI是大肠杆菌的烯酰ACP还原酶。
6. Crystallization and preliminary X-ray crystallographic studies of pig heart carbonyl reductase [O] . Ken-ichi Aoki, Nobutada Tanaka, Shuhei Ishikura, 2006

机译：猪心脏羰基还原酶的结晶和初步X射线晶体学研究
7. Inhibition of carbonyl reductase activity in pig heart by alkyl phenyl ketones [O] . Imamura Yorishige, Narumi Rika, Shimada Hideaki, 2007

机译：烷基苯基酮抑制猪心脏羰基还原酶活性

Comparative inhibition of tetrameric carbonyl reductase activity in pig heart cytosol by alkyl 4-pyridyl ketones

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