Synthesis and antibacterial activity of novel 4-chloro-2-mercaptobenzenesulfonamide derivatives

摘要

Few series of novel 4-chloro-2-mercaptobenzenesulfonamides have been synthesized by the reactions of N-(benzenesulfonyl)cyanamide potassium salts 7-15 with corresponding hydrazinecarbodithioic acid esters, T-substituted carbothioic acid hydrazides, methyl 3-aminothiophene-2-carboxylate, methyl 2-aminobenzoate, 2-aminophenol or 2-aminothiophenol. The synthesized compounds (16-49) were screened in vitro for their antibacterial activity. Some of the tested compounds 16,17, 23, 24,31,32 and 48 showed the promising activity against many of anaerobic Gram-positive bacteria strains.