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Validation of AD-CSF-Index in Chinese Patients With Alzheimer's Disease and Nondemented Controls

机译:中国阿尔茨海默氏病和非痴呆对照患者AD-CSF指数的验证

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Cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD), especially A42/t-tau and A42/p-tau, showed high diagnostic sensitivities and specificities. But significant interassay and interlaboratory variabilities hinder the widespread clinical applications of CSF biomarkers. The objective of this study was to validate the diagnostic accuracy of AD-CSF-Index in our local Chinese patients with AD compared to nondemented controls. A total of 36 patients, which included 24 patients with AD and 12 nondemented controls, were recruited. Chinese patients with AD showed higher mean AD-CSF-Indices than nondemented controls (AD = 1.25-1.3, normal = 0.62-0.63; P < .001). The AD-CSF-indices have a high sensitivity and specificity of 86.4% to 90.9% and 83.3%, respectively, in differentiating patients with AD from nondemented controls. After selecting the patients with pure AD and pure normal controls, the AD-CSF-indices have a high sensitivity and specificity of 94.1% and 90%, respectively, in differentiating patients with AD from nondemented controls. Most importantly, our AD-CSF-indices cutoff was highly similar to that reported in Western studies.
机译:阿尔茨海默氏病(AD)的脑脊液(CSF)生物标志物,尤其是A42 / t-tau和A42 / p-tau,表现出很高的诊断敏感性和特异性。但是显着的测定间和实验室间变异性阻碍了CSF生物标记物的广泛临床应用。这项研究的目的是验证与非痴呆对照相比,AD-CSF-Index对我们中国本地AD患者的诊断准确性。总共招募了36位患者,其中包括24位AD患者和12位非痴呆对照。中国AD患者的平均AD-CSF指数高于非痴呆对照组(AD = 1.25-1.3,正常= 0.62-0.63; P <.001)。 AD-CSF指数在区分AD患者和非痴呆对照者中分别具有86.4%至90.9%和83.3%的高敏感性和特异性。在选择具有纯AD和纯正常对照的患者后,AD-CSF指数在区分AD患者和非痴呆对照方面分别具有94.1%和90%的高敏感性和特异性。最重要的是,我们的AD-CSF指数临界值与西方研究中报道的高度相似。

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