Ovarian solid tumors: Current treatment and recent developments using stimuli-responsive polymers: A systemic review

摘要

Among gynaecologic malignancies, ovarian cancer is the sixth most common cancer leading to death worldwide. Current treatment based on epigenetic strategies use histone deacetylase (HDAC) and DNA methyl tranferase (DNMT) inhibitors have several shortcomings. Further research to develop better inhibitors were terminated due to undesirable toxicity and insignificant results. In recent years researchers have, therefore, shown interest in drug delivery systems (DDS) to enhance the effectiveness of anticancer drugs for ovarian solid tumors. In this context stimuli-responsive polymers, namely temperature, pH, enzyme, light, etc., have shown considerable potential. These polymeric-drug conjugates can extend the circulation half-life of the drugs, decrease the rate of clearance of the drug and its non-specific absorption into the systemic tissues and specifically target tumor tissues passively by the enhanced permeability and retention (EPR) effect and the application of mild hyperthermia. In the present report, to the best of our knowledge we are the first one who review the novel approaches that have been made in the stimuli-responsive polymeric drug delivery systems for the targeted delivery of anticancer drugs to ovarian solid tumors.