Synthesis of a new Pt(II) complex containing valganciclovir drug and calf-thymus DNA interaction study using multispectroscopic methods

摘要

A new complex, [Pt(valcyte)(DMSO) Cl] Cl, in which valcyte (trade name) served as valganciclovir hydrochloride drug ([2-[(2-amino-6- oxo-3H-purin-9-yl) methoxy]-3-hydroxypropyl](2S)-2-amino-3- methylbutanoate), was synthesized and characterized by different physicochemical methods. Binding interaction of this complex with calf-thymus DNA (ct-DNA) has been investigated by multispectroscopic techniques. The complex displays significant binding properties with ct-DNA. The results of fluorescence and UVvis absorption spectroscopy indicated that this complex interacted with ct-DNA in a groove-binding mode, and the binding constant was 3.8 x 104 M-1. Furthermore, the complex induced detectable changes in the CD spectrum of ct-DNA and slightly changed its viscosity which verified the groove-binding mode. Finally, all results indicated that Pt(II) complex interact with DNA via groove-binding mode.