Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.

Ujjwal Neogi; Shwetha D Rao; Irene Bontell; Jens Verheyen; Vasudev R Rao; Sagar C Gore; Neelesh Soni; Anita Shet; Eugen Schülter; Maria L Ekstrand; Amogne Wondwossen; Rolf Kaiser; Mallur S Madhusudhan; Vinayaka R Prasad; Anders Sonnerborg

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Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.

机译：在印度裔患者的HIV-1亚型C的Gag-p6 ALIX结合基序中新的四肽插入与蛋白酶抑制剂失败相关。

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A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratio=17.1, P?

机译：在Gag-p6 ALIX结合区域发现了一种新的四肽插入，该区域出现在蛋白酶抑制剂失效的印度HIV-1C序列中（奇数比= 17.1，P 0.001），但自然存在于未经治疗的埃塞俄比亚HIV中的一半-1C序列。预计该插入将恢复ALIX介导的病毒释放途径，而HIV-1C缺乏这种途径。需要在HIV-1C占主导地位的地区评估插入的临床重要性，在这些地区中蛋白酶抑制剂药物的使用正在扩大。

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《AIDS》 |2014年第15期|共4页
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Ujjwal Neogi; Shwetha D Rao; Irene Bontell; Jens Verheyen; Vasudev R Rao; Sagar C Gore; Neelesh Soni; Anita Shet; Eugen Schülter; Maria L Ekstrand; Amogne Wondwossen; Rolf Kaiser; Mallur S Madhusudhan; Vinayaka R Prasad; Anders Sonnerborg;
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正文语种 eng
中图分类传染病;
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入库时间 2022-08-18 09:58:28

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1. Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients. [J] . Ujjwal Neogi, Shwetha D Rao, Irene Bontell, AIDS . 2014,第15期

机译：在印度裔患者的HIV-1亚型C的Gag-p6 ALIX结合基序中新的四肽插入与蛋白酶抑制剂失败相关。
2. Characterization of HIV type 1 subtype C protease gene: selection of L63P mutation in protease inhibitor-naive Indian patients. [J] . Neogi U, Sahoo PN, Kumar R, AIDS Research and Human Retroviruses . 2011,第11期

机译：HIV 1型C型亚型蛋白酶基因的特征：未使用蛋白酶抑制剂的印度患者中L63P突变的选择。
3. Adherence and Preexisting Major Protease Inhibitor Resistance Mutations are Associated with Virologic Failure of a Dual-Class Antiretroviral Regimen with Inhibitors of HIV-1 Viral Protease and Integrase [J] . Edward M. Gardner, Andre G. Melendez, Maria Astiz, Journal of the International Association of Providers of AIDS Care. . 2012,第1期

机译：粘附和预先存在的主要蛋白酶抑制剂抗性突变与HIV-1病毒蛋白酶和整合酶抑制剂的双重类抗逆转录病毒疗法的病毒学失败有关。
4. Large-Scale Quantum Chemical Calculation on the Complexes of HIV-1 Protease and Inhibitors: A Relationship of Calculation Energies with Drug Effects of Inhibitors [C] . Yoichiro Yagi, Akihiro Iwasa, Yoshinobu Naoshima International Conference on Modeling and Simulation Technology . 2011

机译：HIV-1蛋白酶和抑制剂复合物的大规模量子化学计算：对抑制剂药物效应的计算能量的关系
5. Design and synthesis of core structural intermediates for novel HIV-1 protease inhibitors and synthesis, biological activity and molecular modeling of novel 20S proteasome inhibitors. [D] . Avancha, Kiran Kumar Venkata Raja. 2006

机译：新型HIV-1蛋白酶抑制剂的核心结构中间体的设计与合成，新型20S蛋白酶体抑制剂的合成，生物学活性和分子建模。
6. Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure [O] . Ujjwal Neogi, Shwetha D RAO, Irene BONTELL, -1

机译：与蛋白酶抑制剂失效相关的HIV-1 C亚型的Gag-p6 ALIX结合基序中的新型四肽插入
7. Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients [O] . Ujjwal Neogi, Shwetha D. Rao, Irene Bontell, 2014

机译：在HIV-1亚型C中的GAG-P6 Alix结合基序中的新型四肽插入与印度患者蛋白酶抑制剂失效相关的HIV-1亚型C.

Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.

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