Investigation of antioxidant ability of grape seeds extract to prevent oxidatively induced DNA damage by gas chromatography-tandem mass spectrometry

摘要

Highlights?Main phenolic compounds were determined in methanol extract of grape seeds.?The protective abilities of catechin and cyanidin were tested against the oxidation of DNA.?Cyanidin has high protection ability on oxidative DNA damage.?Structural features affect the preventive activity of antioxidants on oxidative DNA damage.?Proportional relationship between concentration and oxidation inhibition was observed.AbstractPhenolic compounds have been studied elaborately for their efficacy to improve health and to protect against a wide variety of diseases. Herein this study, different analysis methods were implemented to evaluate the antioxidant properties of catechin and cyanidin using their standard substances and as they found in the grape seeds extracts. Total phenol contents were 107.39±8