Failure of bone marrow transplantation to eradicate HIV reservoir despite efficient HAART.

摘要

One of the challenges in HIV infection is viral eradication, as underlined by recent studies . Allogeneic bone marrow transplantation (BMT) has been suggested to be able to reconstitute patients' haematopoietic systems after the clearance of HIV-infected cells with intensive chemotherapy and radiation . In 1999, Huzicka reviewed 32 allogeneic bone marrow transplants in HIV-infected patients between 1982 and 1996; in two cases, HIV seemed to be eradicated as judged by negative HIV-DNA and HIV-RNA levels using classic polymerase chain reaction .