Demarcation line depth after contact lens–assisted corneal crosslinking for?progressive keratoconus: Comparison of?dextran-based and hydroxypropyl methylcellulose–based riboflavin solutions

摘要

Purpose To compare the demarcation line depth after contact lensassisted corneal crosslinking (CXL) for progressive keratoconus using dextran-based and hydroxypropyl methylcellulose (HPMC)-based riboflavin solutions. Setting Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Design Retrospective case series. Methods Patients with preoperative epithelium-on (epi-on) minimum corneal thickness between 350牸m and 450牸m having contact lensassisted CXL for progressive keratoconus were crosslinked with isoosmolar 0.1% riboflavin in 20% dextran 500 or HPMC 1.1%. The primary outcome measure was the mean demarcation line depth measured 1爉onth postoperatively on anterior-segment optical coherence tomography. The secondary outcome measure was change in endothelial cell density (ECD) 6爉onths from baseline. Results The study comprised 21 patients (21 eyes, 9 in the HPMC group and 12 in the dextran group). The mean demarcation line depth was deeper in the HPMC group (308.22牸m牨?4.19 [SD]) than in the dextran group (235.33牨?4.87牸m)? P ?P ??02) even after controlling爁or the preoperative lesser epi-on minimum corneal thickness in the HPMC group (385.56牨13.81牸m) versus the dextran group?413.08牨?9.58牸m)? P ?P ??19 and P ??09, respectively). Conclusion During contact lensassisted CXL, HPMC-based riboflavin seemed to be associated with a deeper demarcation line than dextran-based riboflavin, although both solutions were safe for the endothelium at 6爉onths.