Successful stepdown treatment of pulmonary histoplasmosis with thrice‐weekly liposomal amphotericin B in a hospital‐associated, outpatient infusion centre: A case report

摘要

Summary What is known and objective Amphotericin is the preferred treatment for pulmonary histoplasmosis during pregnancy. The long half‐life of amphotericin supports less than daily administration. Case summary A 28‐year‐old pregnant woman diagnosed with recurrent pulmonary histoplasmosis was initiated on liposomal amphotericin 250?mg (4?mg/kg) intravenously daily. After 2?weeks, the patient was discharged and successfully received 250?mg thrice weekly at a hospital‐associated outpatient infusion centre. After 6?weeks of outpatient treatment, a chest X‐ray demonstrated no remaining disease and therapy was discontinued. What is new and conclusion Administration of thrice‐weekly liposomal amphotericin in a hospital‐associated, outpatient infusion centre may be a promising option for stepdown treatment in patients unable to take itraconazole.