Photobiomodulation leads to enhanced radiosensitivity through induction of apoptosis and autophagy in human cervical cancer cells

Djavid Gholamreza Esmaeeli; Bigdeli Bahareh; Goliaei Bahram; Nikoofar Alireza; Hamblin Michael R

摘要

Abstract > The radiomodulatory effect of photobiomodulation (PBM) has recently been studied in cancer cells. The aim of this study was to investigate cellular mechanisms involved in the X‐ray radiosensitivity of HeLa cells pre‐exposed to PBM. HeLa cells were irradiated with 685?nm laser at different energy densities prior to X‐ray ionizing radiation. After irradiation, clonogenic cell survival, cell death due to apoptosis and autophagy were determined. Levels of intracellular reactive oxygen species (ROS), DNA damage and, cell cycle distribution after PBM were measured. PBM at different energy densities (5–20?J/cm 2 ) was not cytotoxic. However, HeLa cells pre‐exposed to 20?J/cm 2 showed enhanced inhibition of colony formation following ionizing radiation. Enhanced radiosensitivity was due to increased oxidative stress, DNA damage, and radiation‐induced apoptosis and autophagy. These results suggest that 685?nm PBM at a higher energy density could possibly be a promising radiosensitizing agent in cervical cancer, to decrease the radiation dose delivered, and therefore prevent the side‐effects that are associated with cancer radiotherapy. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 最近在癌细胞中研究了光生物调节（PBM）的放射性调节作用。本研究的目的是研究预先暴露于PBM的HELA细胞X射线放射敏感性的细胞机制。在X射线电离辐射之前，用685μm激光照射Hela细胞。在照射后，确定克隆核酸细胞存活，确定凋亡和自噬引起的细胞死亡。测量PBM后细胞内反应性氧物质（ROS），DNA损伤和细胞周期分布的水平。 PBM在不同的能量密度（5-20？J / cm 2 </ sup> ）不是细胞毒性。但是，HeLa细胞预先暴露于20？J / cm 2 </ sup> 在电离辐射后表现出增强的菌落形成抑制。增强的放射敏感性是由于氧化应激，DNA损伤和辐射诱导的凋亡和自噬。这些结果表明，在较高的能量密度下，685·NM PBM可能是宫颈癌中有望的放射腺度引发剂，以减少递送的辐射剂量，因此防止与癌症放射疗法相关的副作用。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-33894/'>《Journal of Biophotonics》</a> <b style="margin: 0 2px;">|</b><span>2017年第12期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Djavid Gholamreza Esmaeeli&option=202" target="_blank" rel="nofollow">Djavid Gholamreza Esmaeeli;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bigdeli Bahareh&option=202" target="_blank" rel="nofollow">Bigdeli Bahareh;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Goliaei Bahram&option=202" target="_blank" rel="nofollow">Goliaei Bahram;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nikoofar Alireza&option=202" target="_blank" rel="nofollow">Nikoofar Alireza;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hamblin Michael R&option=202" target="_blank" rel="nofollow">Hamblin Michael R;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Medical Laser Research CenterAcademic Center for Education Culture and Research (ACECR)Tehran Iran;</p> <p>Laboratory of Biophysics and Molecular Biology Institute of Biochemistry and Biophysics (IBB)University of TehranTehran Iran;</p> <p>Laboratory of Biophysics and Molecular Biology Institute of Biochemistry and Biophysics (IBB)University of TehranTehran Iran;</p> <p>Radiotherapy Department Firoozgar HospitalIran University of Medical Sciences.Tehran Iran;</p> <p>Wellman Center for PhotomedicineMassachusetts General HospitalBoston Massachusetts USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/178.html" title="生物物理学">生物物理学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=photobiomodulation&option=203" rel="nofollow">photobiomodulation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=low-level laser therapy&option=203" rel="nofollow">low-level laser therapy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=ionizing radiation&option=203" rel="nofollow">ionizing radiation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=radiosensitization&option=203" rel="nofollow">radiosensitization;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=autophagy&option=203" rel="nofollow">autophagy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cervical cancer cells&option=203" rel="nofollow">cervical cancer cells;</a> </p> <div class="translation"> 机译：光致调节;低级激光疗法;电离辐射;放射敏化;自噬;宫颈癌细胞; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025420197.html">Photobiomodulation leads to enhanced radiosensitivity through induction of apoptosis and autophagy in human cervical cancer cells</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Djavid Gholamreza Esmaeeli&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Djavid Gholamreza Esmaeeli,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bigdeli Bahareh&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Bigdeli Bahareh,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Goliaei Bahram&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Goliaei Bahram,</a> <a href="/journal-foreign-33894/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of Biophotonics .</a> <span>2017</span><span>,第12期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：光致调节导致通过诱导人宫颈癌细胞的凋亡和自噬引起的放射敏感性</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_detail_thesis/0204121071003.html">Hsp90 Inhibitor SNX-2112 Enhances TRAIL-Induced Apoptosis of Human Cervical Cancer Cells via the ROS-Mediated JNK-p53-Autophagy-DR5 Pathway</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liubing Hu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Liubing Hu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yan Wang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yan Wang,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zui Chen&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Zui Chen,</a> <a href="/journal-foreign-27880/" target="_blank" rel="nofollow" class="tuijian_authcolor">Oxidative Medicine and Cellular Longevity .</a> <span>2019</span><span>,第47期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：HSP90抑制剂SNX-2112通过ROS介导的JNK-P53-自噬 - DR5途径增强了人宫颈癌细胞的凋亡诱导的凋亡</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_detail_thesis/0204120902573.html">Combination of graphene oxide–silver nanoparticle nanocomposites and cisplatin enhances apoptosis and autophagy in human cervical cancer cells</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yu-Guo Yuan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yu-Guo Yuan,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sangiliyandi Gurunathan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Sangiliyandi Gurunathan </a> <a href="/journal-foreign-21750/" target="_blank" rel="nofollow" class="tuijian_authcolor">International Journal of Nanomedicine .</a> <span>2017</span><span>,第1期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：石墨烯 - 银纳米颗粒纳米复合材料和顺铂的组合增强了人宫颈癌细胞的凋亡和自噬</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-279465_thesis/0705016910508.html">Proliferation inhibition and apoptosis induction of Juglone on human cervical cancer HeLa cells</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wei Zhang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wei Zhang,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wenhe Zhu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wenhe Zhu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yan Li&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yan Li,</a> <a href="/conference-foreign-279465/" target="_blank" rel="nofollow" class="tuijian_authcolor">International Conference on Frontiers of Advanced Materials and Engineering Technology .</a> <span>2014</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：juglone对人宫颈癌Hela细胞的增殖抑制和凋亡诱导</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061661226.html">Mechanism of 3,3'-diindolylmethane-induced cell death in human C33A cervical cancer cells: Induction of endoplasmic reticulum stress, apoptosis and the role of growth-arrest and DNA-damage genes</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Han, Jing Y.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Han, Jing Y. </a> <span>2009</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：3,3'-二吲哚基甲烷诱导的人C33A宫颈癌细胞死亡的机制：内质网应激，细胞凋亡以及生长停滞和DNA损伤基因的作用</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/040005351925.html">Photobiomodulation leads to enhanced radiosensitivity through induction of apoptosis and autophagy in human cervical cancer cells</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gholamreza Esmaeeli Djavid&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Gholamreza Esmaeeli Djavid,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bahareh Bigdeli&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Bahareh Bigdeli,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bahram Goliaei&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Bahram Goliaei,</a> <span>-1</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过诱导人宫颈癌细胞的凋亡和自噬光生物调节可提高放射敏感性。</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000128840227.html">Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jen-Pi Tsai&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jen-Pi Tsai,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chien-Hsing Lee&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Chien-Hsing Lee,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tsung-Ho Ying&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Tsung-Ho Ying,</a> <span>2015</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：Licochalcone a通过Pi3k / akt / mtor灭活和自噬抑制增强Licochalcone A诱导的人类宫颈癌细胞凋亡的自噬</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-sun-yat-sen-university-medical-sciences_thesis/0201246728441.html">漆黄素通过调节Apaf-1,ERK和COX-2信号通路诱导人宫颈癌细胞凋亡</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘立群&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 刘立群</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=郭微&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,郭微</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=余文丹&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,余文丹</a> <span> <a href="/journal-cn-6575/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中山大学学报（医学科学版） </a> </span> <span> . 2013</span><span>,第001期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_biological-chemical-engineering_thesis/0201291922701.html">重组海藻凝集素通过诱导细胞凋亡与自噬抑制宫颈癌细胞增殖</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈思琦&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 陈思琦</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=朱漪涵&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,朱漪涵</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=义塘苇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,义塘苇</a> <span> <a href="/journal-cn-38790/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 生物化工 </a> </span> <span> . 2021</span><span>,第006期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201294092874.html">千里光菲灵碱诱导MEK/ERK1/2介导的宫颈癌细胞自噬效应</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=马景蕃&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 马景蕃</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张燕&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张燕</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=叶甘萍&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,叶甘萍</a> <span> <a href="/journal-cn-57041/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国药科大学学报 </a> </span> <span> . 2018</span><span>,第5期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-anatomy_thesis/0201292442398.html">芦荟大黄素通过调节Akt/mTOR和MAPK信号诱导非小细胞肺癌细胞自噬和凋亡</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=申凤鸽&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 申凤鸽</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=葛春坡&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,葛春坡</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=袁鹏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,袁鹏</a> <span> <a href="/journal-cn-5765/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 解剖学杂志 </a> </span> <span> . 2021</span><span>,第S01期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_hebei-medical-journal_thesis/0201290731250.html">汉防己甲素调控Chk1基因对宫颈癌细胞增殖、凋亡及放射敏感性的影响</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=龚妙添&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 龚妙添</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨桂生&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨桂生</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=黄仕尧&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,黄仕尧</a> <span> <a href="/journal-cn-6603/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 河北医药 </a> </span> <span> . 2021</span><span>,第020期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-66193_thesis/020222965881.html">雷公藤单体ZST93通过凋亡和自噬通路抑制人胰腺癌细胞增殖并增加吉西他滨化疗敏感性</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王峰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王峰</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=田孝东&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,田孝东</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张正奎&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张正奎</a> <span> <a href="/conference-cn-66193/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第六届全国雷公藤学术会议 </a> <span> <span> . 2017</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020316119289.html">电离辐射诱导人鼻咽癌细胞系CNE-2细胞自噬及自噬抑制与CNE-2细胞放射敏感性关系的研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=周支瑞&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 周支瑞</a> <span> . 2013</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120108419410.html">石斛酚在制备抑制子宫颈癌细胞增殖和诱导子宫颈癌细胞自噬凋亡药物中的应用</a> <b>[P]</b> . <span> 中国专利： CN105943523A </span> <span> . 2016-09-21</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/061202966603.html">一种近距离放射线诱导癌细胞凋亡模型装置</a> <b>[P]</b> . <span> 中国专利： CN106047701B </span> <span> . 2018.08.07</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130401308310.html">humanized antibody that binds human cd20, composition, manufactured article, apoptosis induction method, cd20 positive cancer treatment method, autoimmune disease treatment methods, isolated nucleic acids, expression vectors, host cells, method for producing a humanized 2h7 antibody, isolated polypeptide, liquid formulation, method of treating rheumatoid arthritis (ra) and humanized cd20 binding antibodies</a> <b>[P]</b> . <span> 外国专利：  BRPI0316779B1 </span> <span> . 2020-04-28</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：结合人cd20的人源化抗体，组合物，制成品，凋亡诱导方法，cd20阳性癌症治疗方法，自身免疫性疾病治疗方法，分离的核酸，表达载体，宿主细胞，生产人源化2h7抗体的方法，分离的多肽，液体制剂，治疗类风湿关节炎（ra）和人源化cd20结合抗体的方法 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130440124103.html">Humanized human cd20 binding antibody, composition, manufactured article, apoptosis induction method, cd20 positive cancer treatment method, autoimmune disease treatment methods, isolated nucleic acids, expression vectors, host cells, method for the production of a humanized 2h7 antibody, isolated polypeptide, liquid formulation, method of treating rheumatoid arthritis (ra) and humanized cd20 binding antibodies</a> <b>[P]</b> . <span> 外国专利：  BR0316779A </span> <span> . 2005-11-01</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：人源化人cd20结合抗体，组成，制造品，凋亡诱导方法，cd20阳性癌症治疗方法，自身免疫性疾病治疗方法，分离的核酸，表达载体，宿主细胞，人源化2h7抗体的生产方法，分离的多肽，液体制剂，类风湿关节炎（ra）和人源化cd20结合抗体的治疗方法 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130446856490.html">Apoptosis induction process, cell extermination process, homodimeric, heterodimeric, cervical cancer treatment process, vector and nucleotide sequence</a> <b>[P]</b> . <span> 外国专利：  BR0013160A </span> <span> . 2002-07-30</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：凋亡诱导过程，细胞消除过程，同二聚体，异二聚体，宫颈癌治疗过程，载体和核苷酸序列 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704025420197','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche">  </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)" title="意见反馈">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);" title="回到顶部">回到顶部</a> </li> <li class="shouye"> <a href="/" title="首页">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html" title="关于掌桥">关于掌桥</a></li> <li><a href="/help/helpmap.html" title="资源导航">资源导航</a></li> <li><a href="/help/helpguide.html" title="新手指南">新手指南</a></li> <li><a href="/help/helpcenter.html" title="常见问题">常见问题</a></li> <li><a href="/sitemap.html" title="网站地图">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9" title="版权声明">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank" title="ICP备案号">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704025420197down" data-source="7," data-out-id="8AA1qd5YBIy/nDXp6ynPlgaQBt2Oq3YbM5ynz/203t+MC7b96Q1VpP1oBnVxP/A4," data-f-source-id="7" data-title="Photobiomodulation leads to enhanced radiosensitivity through induction of apoptosis and autophagy in human cervical cancer cells" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="33894" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="Photobiomodulation leads to enhanced radiosensitivity through induction of apoptosis and autophagy in human cervical cancer cells"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/newmail.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.7.8"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/sse.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.7.8"></script> </body> <script> $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>