Efficient Synthesis of Flaccidoside 11, a Bioactive Component of Chinese Folk Medicine Di Wu

摘要

A bidesmosidic triterpene saponin, flaccidoside II, which was isolated from Di Wu, a Chinese folk medicine from dry rhizome of Anemone flaccida Fr. Schmidt, was efficiently-synthesized in a convergent approach. We employed two glycosyl trichloroacetimidate donors in a one-pot reaction as a key step.[Supplementary materials are available for this article. Go to the publisher's online edition of the Journal of Carbohydrate Chemistry for the following free supplemental resource(s): ~1H NMR, ~13C NMR and HR mass spectra for all synthesized compounds, 2,6, 9-11, and Flaccidoside II (1)