Reply to 'TLR-2 ligand lipomannan from Mycobacterium tuberculosis does not stimulate inflammatory cytokines in dendritic cells'

摘要

We thank Hedge et al. [1] for sharing their data obtained with monocyte-derived dendritic cells stimulated with Mycobacterium tuberculosis (MTB)-derived lipomannan. We agree that future studies investigating Тоll-like receptor (TLR)2-mediated responses should use a TLR2 ligand derived from the mycobacteria species of interest when one is available. For example, inactivated or whole cell lysate of pathogenic MTB containing all types of TLR2 ligands can be used to investigate immune restoration disease (IRD) associated with MTB infections. We used lipomannan from Mycobacterium smegmatis to demonstrate elevated responses in primary isolate cells from HIV coinfected patients experiencing an IRD associated with MTB [2].