Successful drug treatment of immune reconstitution disease with the leukotriene receptor antagonist, montelukast: a clue to pathogenesis?

摘要

Immune reconstitution disease (IRD) is a common clinical syndrome that typically presents as symptoms developing within a few weeks of starting antiretroviral therapy . The pathogenesis is not fully understood, but is thought to relate to changes in the immune response directed against local antigen , Even when there is no obvious specific trigger, the symptoms can be prolonged and severe , Treatment is often with steroids, which carry a degree of risk in an HIV4nfected population . A recent report highlighted the potential value of the leukotriene receptor antagonist, montelukast, in IRD . Here we describe its use in a case of urticarial vasculitis associated with antiretroviral therapy.