Diabetes Mellitus Increases Risk of Incident Dementia in APOE epsilon 4 Carriers: A Meta-Analysis

摘要

Background: Dementia is a devastating condition for older adults, with both modifiable (e.g., diabetes mellitus) and unmodifiable risk factors (e.g., APOE epsilon 4 allele). It remains unclear how, and to what extent, diabetes impacts dementia risk via both cerebrovascular and amyloid-beta pathways.