Preparation and Performance Characterization of Bioactive Coating on Magnesium Alloy

摘要

Background: Magnesium and its alloys feature low density, high specific strength, and biodegradability. However, latent toxic effects, relative poor biocompatibility, and rapid corrosion rate have restricted clinical application. Surface modification, especially micro-arc oxidation (MAO), could greatly improve the surface biocompatibility, biosafety, and biological activity of magnesium-based implants. Methods: A bioactive coating was prepared on the surface of magnesium alloy using MAO in a zinc- containing electrolyte. Surface morphology and topography, thickness, and zinc content of the bioactive coating were studied by scanning electron microscopy (SEM), atomic force microscope (AFM), eddy current thickness metering, and energy dispersive spectroscopy (EDS). Biocompatibility of the zinc-containing coating was analyzed by hemolysis testing. Results: A coarse and porous coating composed of Mg, Al, O, P and Zn was prepared on the surface of the magnesium alloy, and Zn was uniformly distributed in the coating. The coating displayed pronounced biocompatibility with blood. Conclusions: Zn-containing bioactive coating can be formed on the surface of magnesium alloy by MAO. The coating has high biocompatibility with blood and had potential clinical applications.