Difference between two exhaled nitric oxide analyzers, NIOX VEROA (R) electrochemical hand-held analyzer and NOA280iA (R) chemiluminescence stationary analyzer

摘要

Background: Fractional exhaled nitric oxide (FENO) is useful for the evaluation of eosinophilic airway inflammation, including that seen in asthma. Although a new electrochemical hand-held FENO analyzer, the NIOX VEROA (R) (Aerocrine AB, Solna, Sweden), is clinically convenient to use, it has not been fully compared with the chemiluminescence stationary electrochemical analyzer NOA280iA (R) (Sievers Instruments, Boulder, CO, USA) in terms of the level of measured FENO. The aim of this study was to determine whether there is a difference between the two analyzers. Methods: The FENO levels measured with both NIOX VEROA (R) and NOA280iA (R) were evaluated in 1,369 adults at Juntendo University Hospital from May 2016 to October 2016. Results: The median FENO level measured with the NIOX VEROA (R) was significantly lower than that measured with the NOA280iA (R) (41 ppb, range 5-368 ppb vs. 29 ppb, range 5-251 ppb; p < 0.001). There was a strong positive correlation in the measurement of FENO level between the NOA280i (R) and the NIOX VEROA (R) (r = 0.942, p < 0.001). The following conversion equation was calculated: FENO (NOA280iA (R)) = 1.362 (SE, 0.661) + 1.384 (SE, 0.021) x FENO (NIOX VEROA (R)). Conclusions: To our best knowledge, we have provided the first report showing that the measured FENO level with the NIOX VEROA (R) was approximately 30% lower than that with the NOA280iA (R) and that there was a significant correlation between the measurements of these two devices. The correction equation that we provided may help assess the data obtained by these two analyzers.