Regulatory Functions of Amino Acids and Their Combinations in Prokaryotes and Tissues of Higher Organisms

摘要

The influence of individual amino acids and their combinations on the growth of cultures of Escherichia coli 075 and the proliferation of the culture of organotypic tissues was studied. Based on their effect on the colony size, all amino acids were divided into neutral, stimulating, and inhibiting with regard to growth. The biological effect of amino acids was associated with the concentration of amino acids and was dependent on the heterogeneity of the bacterial population. The activity of two aminoacids, which occur in pairs, was different from the activity of individual compounds. Some combinations of amino acids, which cause recognizable elfects in bacterial cultures, also had an effect on the tissue cultures of mammals. It was shown that the combinations of amino acids that constitute peptides were less active than the original peptide.