What DNA methylation modifications and/or genetic variations interact with childhood maltreatment in the development of depression: A systematic review

摘要

Background: Child maltreatment predicts a significant risk factor for depression. The relationship between child maltreatment and depression has been shown to vary as a function of genetic factors. There have been very few systematic reviews conducted to date to synthesize what DNA methylations and/ or genetic variations interact with childhood maltreatment in the course of depression. This systematic review aimed to provide an overview of DNA methylation modifications with/without genetic variations associated with childhood maltreatment in depression.