A Novel Correlation for Protein Diffusion Coefficients Based on Molecular Weight and Radius of Gyration

摘要

A new correlation is proposed for the prediction of protein diffusion coefficients in free solution.Molecular weight and radius of gyration of proteins are employed as correlation parameters in this method Both parameters an be easily found in the loterature.The corfelation works well for diverse proteins with dfifferent spapes and extensive molecular weight.Furthermore thsi method does not requrie a preassump-tion regarding the protein shape while it offers a rapid and conventient calculation with a high acfcuracy Also the proposed correlation can elucidate the estimation deviation of previous correlation methods in the literature.