CHOLINE CHLORIDE CATALYZED ECO-FRIEND AND EFFECTIVE ONE-POT SYNTHESIS OF 9-ARYLACRIDINE-1,8-DIONE AND HEXAHYDROQUINOLINE VIA HANTZSCH TYPE REACTION

摘要

Choline chloride was utilized to efficiently catalyzed Hantzsch type reaction for the synthesis of 9-arylacridine-1,8-dione and hexahydroquinoline derivatives. The optimized catalytic system benefits from facile operation and separation procedures, in good to excellent yields, and for wide substrate tolerance. This methodology is of interest also due to employing simple and inexpensive choline chloride as catalyst and environmentally benign ethanol as solvent without the use of any harmful organic solvent and toxic metal catalyst.